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是肝细胞癌中的一种新型预后生物标志物。

is a New Prognostic Biomarker in Hepatocellular Carcinoma.

作者信息

Lu Haoran, Zhao Rou, Qin Qianqian, Tang Liyong, Ma Guodong, He Baoyu, Liang Jing, Wei Li, Wang Xutong, Bie Qingli, Wang Xuning, Zhang Bin

机构信息

Department of Hepatobiliary Surgery, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, People's Republic of China.

Department of Laboratory Medicine, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, People's Republic of China.

出版信息

Int J Gen Med. 2023 May 1;16:1603-1619. doi: 10.2147/IJGM.S408651. eCollection 2023.

DOI:10.2147/IJGM.S408651
PMID:37152272
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10162392/
Abstract

BACKGROUND

Hepatocellular carcinoma (HCC) is one of the most common type of cancers, but there is still a lack of known biomarkers for the effective diagnosis or prognosis of HCC. Myristoylated alanine-rich C-kinase substrate (MARCKS) is a substrate of protein kinase C, which was located in the cell plasma membrane. The purpose of our study was to evaluate the role of MARCKS in HCC.

METHODS

The role of MARCKS in HCC was explored by bioinformatics and experiment.

RESULTS

We demonstrated that MARCKS expression was significantly elevated in HCC datasets of TCGA. MARCKS was up-regulated in tumor sample in HCC. Functional enrichment indicated that MARCKS-related differentially expressed genes (DEGs) were mainly enriched in cell junction tissue, response to growth factors and cell population proliferation. Tumor and ECM-receptor interactions related pathways were enriched by the KEGG. MARCKS expression in HCC patients was higher in females, younger individuals, and those at worse clinical stages. Cox regression analysis showed that MARCKS expression was a risk factor for overall survival and disease-specific survival of patients.

CONCLUSION

MARCKS was up-regulated in HCC, may play a crucial role in HCCs, and has prognostic value for clinical outcomes.

摘要

背景

肝细胞癌（HCC）是最常见的癌症类型之一，但仍缺乏用于HCC有效诊断或预后的已知生物标志物。富含肉豆蔻酰化丙氨酸的蛋白激酶C底物（MARCKS）是蛋白激酶C的一种底物，位于细胞质膜中。我们研究的目的是评估MARCKS在HCC中的作用。

方法

通过生物信息学和实验探索MARCKS在HCC中的作用。

结果

我们证明在TCGA的HCC数据集中MARCKS表达显著升高。在HCC的肿瘤样本中MARCKS上调。功能富集表明，与MARCKS相关的差异表达基因（DEGs）主要富集在细胞连接组织、对生长因子的反应和细胞群体增殖中。KEGG富集了与肿瘤和细胞外基质-受体相互作用相关的途径。HCC患者中MARCKS表达在女性、年轻个体和临床分期较差的患者中较高。Cox回归分析表明，MARCKS表达是患者总生存和疾病特异性生存的危险因素。

结论

MARCKS在HCC中上调，可能在HCC中起关键作用，并且对临床结局具有预后价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a37/10162392/dc827828c5b4/IJGM-16-1603-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a37/10162392/f1773d9ebe24/IJGM-16-1603-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a37/10162392/978b2a22d6c6/IJGM-16-1603-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a37/10162392/b4d03026c34e/IJGM-16-1603-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a37/10162392/403be965d474/IJGM-16-1603-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a37/10162392/42f26286ed0c/IJGM-16-1603-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a37/10162392/d9938f244255/IJGM-16-1603-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a37/10162392/a4f171131412/IJGM-16-1603-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a37/10162392/dc827828c5b4/IJGM-16-1603-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a37/10162392/f1773d9ebe24/IJGM-16-1603-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a37/10162392/978b2a22d6c6/IJGM-16-1603-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a37/10162392/b4d03026c34e/IJGM-16-1603-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a37/10162392/403be965d474/IJGM-16-1603-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a37/10162392/42f26286ed0c/IJGM-16-1603-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a37/10162392/d9938f244255/IJGM-16-1603-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a37/10162392/a4f171131412/IJGM-16-1603-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a37/10162392/dc827828c5b4/IJGM-16-1603-g0008.jpg

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本文引用的文献

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