Strony John T, Raji Yazdan, Ina Jason G, Yu Jiao, Megerian Mark F, McCollum Samuel W, Mather Richard C, Nho Shane J, Salata Michael J
University Hospitals Cleveland Medical Center, Cleveland, Ohio, USA.
School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Orthop J Sports Med. 2023 May 1;11(5):23259671231162340. doi: 10.1177/23259671231162340. eCollection 2023 May.
On August 31, 2017, Ohio passed legislation that regulates how opioids can be prescribed postoperatively. Studies have shown that such legislation is successful in reducing the morphine milligram equivalents (MMEs) prescribed after certain orthopaedic procedures.
(1) To determine if the opioid prescription-limiting legislation in Ohio reduced the cumulative MMEs prescribed after hip arthroscopy without significantly affecting the rates of emergency department (ED) visits, hospital readmissions, and reoperations within 90 days postoperatively, and (2) to assess risk factors associated with increased postoperative opioid dosing.
Cohort study; Level of evidence, 3.
This study included patients who underwent primary and revision hip arthroscopy at a single institution over a 4-year period. The prelegislation (PRE) and postlegislation (POST) groups were defined as patients who underwent surgery before August 31, 2017, and on/after this date, respectively. The Ohio Automated Rx Reporting System was queried for controlled-substance prescriptions from 30 days preoperatively to 90 days postoperatively, and patient medical records were reviewed to collect demographic, medical, surgical, and readmission data. Inverse probability weighting-adjusted mean treatment effect regression models were used to measure the difference in mean outcomes between the PRE and POST cohorts.
A total of 546 patients (228 PRE, 318 POST) were identified. There was a 25% reduction in the cumulative MMEs prescribed to the POST group as compared with the PRE group during the first 90 days postoperatively (840 vs 1125 MME, respectively; < .01). The legislation was associated with a significant decrease in the cumulative MMEs prescribed in the first 90 postoperative days (mean treatment effect = -280.6; < .01), and there were no significant between-group differences in the frequency of ED encounters (8.8% PRE, 11.6% POST; = .32), hospital readmissions (1.3% PRE, 0.9% POST; = .70), or reoperations (0.9% PRE, 0.6% POST; ≥ .99) during this period. Preoperative opioid use was a significant independent risk factor for increased cumulative MMEs in the first 90 days postoperatively (β = 275; < .01).
Opioid prescription-limiting legislation in Ohio was associated with significant reductions in opioid MMEs dosing in the 90-day period following hip arthroscopy. This legislation had no significant effect on ED utilization, hospital readmissions, or reoperations within the same period. Preoperative opioid use was a significant risk factor for increased MME dosing after hip arthroscopy.
2017年8月31日,俄亥俄州通过了一项立法,规定了术后阿片类药物的处方方式。研究表明,此类立法在减少某些骨科手术后开具的吗啡毫克当量(MMEs)方面是成功的。
(1)确定俄亥俄州的阿片类药物处方限制立法是否降低了髋关节镜检查后开具的累积MMEs,同时不显著影响术后90天内的急诊科(ED)就诊率、医院再入院率和再次手术率;(2)评估与术后阿片类药物剂量增加相关的风险因素。
队列研究;证据等级,3级。
本研究纳入了在4年期间于单一机构接受初次和翻修髋关节镜检查的患者。立法前(PRE)组和立法后(POST)组分别定义为在2017年8月31日之前和该日期当天及之后接受手术的患者。查询俄亥俄州自动处方报告系统,获取术前30天至术后90天的受控物质处方,并审查患者病历以收集人口统计学、医学、手术和再入院数据。使用逆概率加权调整的平均治疗效果回归模型来测量PRE组和POST组之间平均结果的差异。
共识别出546例患者(228例PRE组,318例POST组)。与PRE组相比,POST组在术后前90天开具的累积MMEs减少了25%(分别为840 MME和1125 MME;P <.01)。该立法与术后前90天开具的累积MMEs显著减少相关(平均治疗效果 = -280.6;P <.01),在此期间,两组之间的ED就诊频率(PRE组8.8%,POST组11.6%;P =.32)、医院再入院率(PRE组1.3%,POST组0.9%;P =.70)或再次手术率(PRE组0.9%,POST组0.6%;P ≥.99)无显著差异。术前使用阿片类药物是术后前90天累积MMEs增加的显著独立风险因素(β = 275;P <.01)。
俄亥俄州的阿片类药物处方限制立法与髋关节镜检查后90天内阿片类药物MMEs剂量的显著减少相关。该立法对同期的ED利用率、医院再入院率或再次手术率没有显著影响。术前使用阿片类药物是髋关节镜检查后MME剂量增加的显著风险因素。