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卵巢癌肉瘤与免疫治疗反应

Ovarian Carcinosarcoma and Response to Immunotherapy.

作者信息

Daniyal Muhammad, Polani Anamm S, Canary Marcy

机构信息

Internal Medicine, Bassett Hospital, Cooperstown, USA.

Hematology and Medical Oncology, Bassett Hospital, Cooperstown, USA.

出版信息

Cureus. 2023 Apr 5;15(4):e37149. doi: 10.7759/cureus.37149. eCollection 2023 Apr.

DOI:10.7759/cureus.37149
PMID:37153309
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10161148/
Abstract

Ovarian carcinosarcoma (OCS) is an uncommon and highly aggressive subtype of ovarian cancer. This form of cancer is characterized by limited treatment options and a poor prognosis. In this report, we present a case study of a 64-year-old female diagnosed with stage III OCS, who underwent debulking surgery and adjuvant chemotherapy, followed by immunotherapy, with encouraging outcomes. Despite the availability of diverse chemotherapy options, the prognosis for patients with OCS remains grim. However, the present case study of a 64-year-old female with OCS illustrates the promising outcomes achieved with immunotherapy. Additionally, this case highlights the significance of microsatellite instability testing in guiding treatment decisions for ovarian cancers of this nature.

摘要

卵巢癌肉瘤(OCS)是一种罕见且侵袭性很强的卵巢癌亚型。这种癌症的特点是治疗选择有限且预后不良。在本报告中,我们展示了一例64岁女性被诊断为III期OCS的病例研究,该患者接受了肿瘤细胞减灭术和辅助化疗,随后进行了免疫治疗,取得了令人鼓舞的结果。尽管有多种化疗选择,但OCS患者的预后仍然严峻。然而,本例64岁OCS女性的病例研究表明免疫治疗取得了有希望的结果。此外,该病例突出了微卫星不稳定性检测在指导此类卵巢癌治疗决策中的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b92/10161148/a3fb1e4f2893/cureus-0015-00000037149-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b92/10161148/46ebd6db0313/cureus-0015-00000037149-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b92/10161148/a3fb1e4f2893/cureus-0015-00000037149-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b92/10161148/46ebd6db0313/cureus-0015-00000037149-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b92/10161148/a3fb1e4f2893/cureus-0015-00000037149-i02.jpg

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本文引用的文献

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Compartment-specific multiomic profiling identifies SRC and GNAS as candidate drivers of epithelial-to-mesenchymal transition in ovarian carcinosarcoma.特定隔室的多组学分析确定 SRC 和 GNAS 为卵巢癌肉瘤上皮间质转化的候选驱动因素。
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