Department of Gastroenterology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Shaanxi Province Key Laboratory of Gastrointestinal Motility Disorders, Laboratory of Digestive Diseases of the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Front Immunol. 2023 Apr 19;14:1176639. doi: 10.3389/fimmu.2023.1176639. eCollection 2023.
CCL13/MCP-4 belongs to the CC chemokine family, which induces chemotaxis in many immune cells. Despite extensive research into its function in numerous disorders, a thorough analysis of CCL13 is not yet accessible. The role of CCL13 in human disorders and existing CCL13-focused therapies are outlined in this study. The function of CCL13 in rheumatic diseases, skin conditions, and cancer is comparatively well-established, and some studies also suggest that it may be involved in ocular disorders, orthopedic conditions, nasal polyps, and obesity. We also give an overview of research that found very little evidence of CCL13 in HIV, nephritis, and multiple sclerosis. Even though CCL13-mediated inflammation is frequently linked to disease pathogenesis, it's fascinating to note that in some conditions, like primary biliary cholangitis (PBC) and suicide, it might even act as a preventative measure.
CCL13/MCP-4 属于 CC 趋化因子家族，能趋化许多免疫细胞。尽管人们对其在多种疾病中的功能进行了广泛的研究，但对 CCL13 的全面分析还不可用。本研究概述了 CCL13 在人类疾病中的作用和现有的以 CCL13 为重点的治疗方法。CCL13 在风湿性疾病、皮肤病和癌症中的功能已得到较为充分的确立，一些研究还表明它可能与眼部疾病、骨科疾病、鼻息肉和肥胖有关。我们还概述了一些研究，这些研究发现 CCL13 在 HIV、肾炎和多发性硬化症中几乎没有证据。尽管 CCL13 介导的炎症通常与疾病发病机制有关，但有趣的是，在某些情况下，如原发性胆汁性胆管炎 (PBC) 和自杀，它甚至可能起到预防措施的作用。
