Susan Monica, Susan Razvan, Lazar Viorica, Bagiu Iulia-Cristina, Mihu Alin Gabriel, Bagiu Radu Vasile, Ionescu Alin, Iana Andreea Narcisa, Dehelean Cristina Adriana, Lighezan Daniel, Marti Daniela Teodora
Department of Internal Medicine, Centre for Preventive Medicine, Victor Babes University of Medicine and Pharmacy, Timisoara 300041, Romania.
Department of Family Medicine, Centre for Preventive Medicine, Victor Babes University of Medicine and Pharmacy, Timisoara 300041, Romania.
Exp Ther Med. 2023 Apr 18;25(6):254. doi: 10.3892/etm.2023.11953. eCollection 2023 Jun.
The future waves of COVID 19 infections will continue to raise serious problems in patients with severe forms of the disease. Bacterial infections associated with SARS-CoV-2 disease may complicate the progress of hospitalized patients with COVID-19. The present study aimed to evaluate the etiological spectrum of superinfection in adult patients with COVID-19 and to investigate the correlation between superinfection with multidrug-resistant (MDR) bacteria and serum procalcitonin (PCT). A total of 82 COVID-19 hospitalized patients with COVID-19 and bacterial superinfection were included. The superinfections were classified into early infections (3-7 days from admission) and late infections (>7 days from admission). Bacterial superinfection etiological spectrum, MDR bacteria profile and levels of serum PCT were studied. The most frequently isolated bacteria were , and MDR bacteria were involved in 73.17% of COVID-19 patients with bacterial superinfections. Most MDR bacteria superinfections (73.52%) occurred in the late infection period. , . and were the most common MDR bacteria identified in late infections after hospitalization in 20.43, 4.30 and 4.30% of all infections, respectively. Serum PCT values were significantly higher in patients with MDR bacteria superinfection compared with patients with sensitive bacteria superinfection (P=0.009). The principal findings of the present study were the high prevalence of superinfection with MDR bacteria among the COVID-19 patients with bacterial superinfections and the presence of a statistically significant association between serum PCT levels and the presence of superinfection with MDR bacteria. The most effective way to fight against microbial resistance to antibiotics, whether it occurs independently or overlaps with viral infections, is to pursue a national policy for the rational use of antibiotics.
新型冠状病毒肺炎（COVID - 19）未来的感染浪潮将继续给重症患者带来严重问题。与SARS-CoV-2疾病相关的细菌感染可能会使COVID-19住院患者的病情复杂化。本研究旨在评估成年COVID-19患者二重感染的病原体谱，并探讨多重耐药（MDR）菌二重感染与血清降钙素原（PCT）之间的相关性。共纳入82例住院的COVID-19合并细菌二重感染患者。二重感染分为早期感染（入院后3 - 7天）和晚期感染（入院后>7天）。研究了细菌二重感染的病原体谱、MDR菌谱及血清PCT水平。最常分离出的细菌是……，MDR菌在73.17%的COVID-19合并细菌二重感染患者中出现。大多数MDR菌二重感染（73.52%）发生在晚期感染阶段。……、……和……是住院后晚期感染中最常见的MDR菌，分别占所有感染的20.43%、4.30%和4.30%。与敏感菌二重感染患者相比，MDR菌二重感染患者的血清PCT值显著更高（P = 0.009）。本研究的主要发现是，在COVID-19合并细菌二重感染患者中，MDR菌二重感染的发生率很高，且血清PCT水平与MDR菌二重感染之间存在统计学上的显著关联。对抗抗生素微生物耐药性的最有效方法，无论其是独立发生还是与病毒感染重叠，都是推行国家抗生素合理使用政策。
