Liu Hongyuan, Wang Ruofan, Li Xulong, Wu Zhengyang, Sun Jinli, Lu Weiyi, Wang Xianli
School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China.
Sheng Wu Gong Cheng Xue Bao. 2023 Apr 25;39(4):1332-1350. doi: 10.13345/j.cjb.220549.
Organoid is a newly developed cellular there-dimensional culture system in recent years. Organoids have a three-dimensional structure, which is similar to that of the real organs. Together with the characteristics of self-renewal and reproduction of tissue origin, organoids can better simulate the function of real organs. Organoids provide a new platform for the study of organogenesis, regeneration, disease pathogenesis, and drug screening. The digestive system is an essential part of the human body and performs important functions. To date, organoid models of various digestive organs have been successfully established. This review summarizes the latest research progress of organoids of taste buds, esophagi, stomachs, livers and intestines, and prospects future application of organoids.
类器官是近年来新开发的一种细胞三维培养系统。类器官具有三维结构,与真实器官相似。类器官具有组织来源的自我更新和增殖特性,能够更好地模拟真实器官的功能。类器官为器官发生、再生、疾病发病机制和药物筛选的研究提供了一个新平台。消化系统是人体的重要组成部分,发挥着重要功能。迄今为止,各种消化器官的类器官模型已成功建立。本文综述了味蕾、食管、胃、肝脏和肠道类器官的最新研究进展,并对类器官的未来应用进行了展望。