Department of Clinical Neurological Sciences, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada.
Department of Neurology, Oslo University Hospital, Oslo, Norway.
Eur J Neurol. 2023 Aug;30(8):2267-2277. doi: 10.1111/ene.15836. Epub 2023 May 21.
The declining incidence of stroke, ischaemic heart disease (IHD) and dementia (the 'triple threat') in Norway encourages further investigation. The risks and trends of the three conditions were analysed using data from the Global Burden of Disease study.
Global Burden of Disease 2019 estimations were used for age-, sex- and risk-factor-specific incidence and prevalence of the 'triple threat', their risk-factor-attributed deaths and disability combined, their age-standardized rates per 100,000 population in 2019 and their changes during 1990-2019. Data are presented as means and 95% uncertainty intervals.
In 2019, 71.1 thousand Norwegians were living with dementia, 157.2 thousand with IHD and 95.2 thousand with stroke. In 2019, there were 9.9 thousand (8.5 to 11.3) new cases of dementia (35.0% increase since 1990), 17.0 thousand (14.6 to 19.6) with IHD (3.6% decrease) and 8.0 thousand (7.0 to 9.1) with stroke (12.9% decrease) in Norway. During 1990-2019, their age-standardized incidence rates decreased significantly-dementia by -5.4% (-8.4% to -3.2%), IHD by -30.0% (-31.4% to -28.6%) and stroke by -35.3% (-38.3% to -32.2%). There were significant declines in the attributable risks to both environmental and behavioural factors in Norway, but contradictory trends for metabolic risk factors during 1990-2019.
The risk of the 'triple threat' conditions is declining in Norway, despite the increased prevalence. This offers the opportunity to find out why and how and to accelerate their joint prevention through new approaches and the promotion of the National Brain Health Strategy.
挪威的中风、缺血性心脏病(IHD)和痴呆(“三重威胁”)发病率呈下降趋势,这促使我们进一步开展研究。本研究使用全球疾病负担研究的数据,分析了这三种疾病的风险和趋势。
本研究使用了 2019 年全球疾病负担研究的估计数据,分析了“三重威胁”的年龄、性别和风险因素特异性发病率和患病率、其归因于风险因素的死亡和残疾的综合情况、2019 年每 10 万人中标准化发病率以及 1990 年至 2019 年期间的变化情况。数据以平均值和 95%的置信区间表示。
2019 年,挪威有 7.11 万人患有痴呆症,15.72 万人患有 IHD,9.52 万人患有中风。2019 年,挪威有 9900 例(8500 至 11300 例)新发痴呆症(自 1990 年以来增加了 35.0%)、1.70 万例(14600 至 19600 例)IHD(减少 3.6%)和 8000 例(7000 至 9100 例)中风(减少 12.9%)。1990 年至 2019 年期间,这三种疾病的年龄标准化发病率显著下降——痴呆症下降了 5.4%(8.4%至 3.2%)、IHD 下降了 30.0%(31.4%至 28.6%)、中风下降了 35.3%(38.3%至 32.2%)。挪威的环境和行为风险因素的归因风险显著下降,但代谢风险因素在 1990 年至 2019 年期间呈现出相反的趋势。
尽管“三重威胁”的患病率有所增加,但挪威的这三种疾病的风险正在下降。这为我们提供了一个机会,可以找出原因和方式,并通过新的方法和促进国家大脑健康战略来加速它们的联合预防。