Zhang Shangbiao, Gao Yan, Xiao Rui, Li Yang, Wang Yanan, Yuan Zheliang
Key Laboratory of the Ministry of Education for, Advanced Catalysis Materials, College of Chemistry and Materials Science, Zhejiang Normal University, 688 Yingbin Road, Jinhua, 321004, P.R. China.
Chemistry. 2023 Jul 20;29(41):e202301283. doi: 10.1002/chem.202301283. Epub 2023 Jun 6.
Herein, the tandem synthesis of various CF Se-containing heterocyclic compounds has been developed, using Tf O as the catalyst and trifluoromethyl selenoxides as the electrophilic trifluoromethylselenolation reagents. This process is characterized by its mild conditions, ease of operation, and good functional group compatibility. A variety of alkynes could be transferred into CF Se-containing indoles, benzofurans, benzothiophenes, isoquinolines and chromenes in good yields. A key step involving the formation of the electrophilic CF Se species was proposed.
在此，已开发出使用三氟甲磺酸酐作为催化剂和三氟甲基亚硒酰化物作为亲电三氟甲基硒化试剂串联合成各种含CFSe的杂环化合物的方法。该过程的特点是条件温和、操作简便且官能团兼容性好。多种炔烃可以以良好的产率转化为含CFSe的吲哚、苯并呋喃、苯并噻吩、异喹啉和色烯。提出了一个涉及亲电CFSe物种形成的关键步骤。
