Geriatrics & Gerontology, Department of Public Health and Primary Care, KU Leuven, Belgium; Department of Geriatric Medicine, UZ Leuven, Belgium.
Geriatrics & Gerontology, Department of Public Health and Primary Care, KU Leuven, Belgium.
Exp Gerontol. 2023 Jul;178:112196. doi: 10.1016/j.exger.2023.112196. Epub 2023 May 16.
To explore the relationship between inflammatory markers and sarcopenia-related traits in sarcopenic older adults.
Baseline data of the ongoing Exercise and Nutrition for Healthy AgeiNg (ENHANce) study were used for a secondary, exploratory, cross-sectional analysis. ENHANce is a 5-armed triple blinded randomized controlled trial, in older adults (>65y) with sarcopenia defined according to the revised criteria of the European Working Group of Sarcopenia in Older People (EWGSOP2) aiming to assess the effect of combined anabolic interventions (protein supplement, omega-3 supplement and physical exercise) on physical performance, compared to single/placebo interventions. Inflammatory markers C-reactive protein (hs-CRP), albumin, interleukin-1β (IL-1β), IL-6, IL-8, and tumour necrosis factor-α (TNF-α) were assessed at baseline. Spearman's rho (ρ) correlation coefficients were calculated to associate these inflammatory markers with baseline sarcopenia-defining parameters (handgrip strength, chair stand test, appendicular lean mass [aLM], gait speed, Short Physical Performance Battery), physical activity (step count) and quality of life (SF-36, SarQoL).
We included 40 sarcopenic subjects (15 men/25 women, age 77.1 ± 6.8 years). Contrary to expectations, the pro-inflammatory IL-1β correlated positively with handgrip strength (ρ: 0.376; p = 0.024) and IL-6 with aLM (ρ: 0.334; p = 0.0433). IL-6 inversely correlated with step count (ρ:-0.358; p = 0.048). Subgroup analysis revealed important gender differences. IL-8 inversely correlated with handgrip strength in women (ρ: -0.425; p = 0.034) but not in men. In contrast, pro-inflammatory cytokines CRP (ρ: -0.615; p = 0.019), IL-6 (ρ: -0.604; p = 0.029) and TNF-α (ρ: -0.615; p = 0.025) inversely correlated with the SF-36 physical component score in men but not in women.
Although Inflammageing might play a role in sarcopenia-related traits, this exploratory study highlights an important role of gender. Future research should take this into account when elucidating the Inflammageing-sarcopenia interplay.
探讨炎症标志物与老年肌少症相关特征之间的关系。
本研究采用正在进行的“运动和营养促进健康老龄化（ENHANce）”研究的基线数据进行二次、探索性、横断面分析。ENHANce 是一项 5 臂、三盲、随机对照临床试验，纳入了根据欧洲老年人肌少症工作组（EWGSOP2）修订标准定义的肌少症老年人（>65 岁），旨在评估联合合成代谢干预（蛋白质补充剂、欧米伽-3 补充剂和身体运动）与单一/安慰剂干预相比对身体表现的影响。在基线时评估炎症标志物 C 反应蛋白（hs-CRP）、白蛋白、白细胞介素-1β（IL-1β）、IL-6、IL-8 和肿瘤坏死因子-α（TNF-α）。使用 Spearman ρ 相关系数来关联这些炎症标志物与基线肌少症定义参数（握力、椅上站立试验、四肢瘦体重[aLM]、步态速度、简易体能状况量表）、身体活动（步数）和生活质量（SF-36、SarQoL）。
我们纳入了 40 名肌少症患者（15 名男性/25 名女性，年龄 77.1±6.8 岁）。与预期相反，促炎细胞因子 IL-1β与握力呈正相关（ρ：0.376；p=0.024），IL-6 与 aLM 呈正相关（ρ：0.334；p=0.0433）。IL-6 与步数呈负相关（ρ：-0.358；p=0.048）。亚组分析显示出重要的性别差异。IL-8 与女性的握力呈负相关（ρ：-0.425；p=0.034），但与男性无关。相反，促炎细胞因子 CRP（ρ：-0.615；p=0.019）、IL-6（ρ：-0.604；p=0.029）和 TNF-α（ρ：-0.615；p=0.025）与男性的 SF-36 身体成分评分呈负相关，但与女性无关。
尽管炎症衰老可能在肌少症相关特征中起作用，但本探索性研究强调了性别起着重要作用。未来的研究在阐明炎症衰老与肌少症的相互作用时，应该考虑到这一点。
