Prianishnikov V A
Arkh Patol. 1979;41(1):60-6.
A model of functional-morphological organization of epithelium of human normal, hyperplastic, and tumour endometrium is described. The model is based on a hypothesis that a population of stem cells capable of indefinite unlimited self-maintenance exists in normal glandular epithelium of the endometrium. The population of normal stem cells of endometrium epithelium is the source of emergence of differentiated types of epithelial cells among which, according to the model, three cell types can be distinguished: cells sensitive to estradiol alone, cells sensitive to both estradiol and progesteron, and cells sensitive to progesteron alone. The conditions necessary for transition of one cell type to another as well as histochemical characteristics of each of the cell types are described. The model has been used for the analysis of morphological changes developing in hyperplastic processes and cancer of the endometrium as well as for the substantiation of the current schedules for hormone therapy of these diseases.
描述了人正常、增生性和肿瘤性子宫内膜上皮功能-形态组织模型。该模型基于这样一种假设：子宫内膜正常腺上皮中存在能够无限自我维持的干细胞群体。子宫内膜上皮正常干细胞群体是分化型上皮细胞出现的来源，根据该模型，可以区分出三种细胞类型：仅对雌二醇敏感的细胞、对雌二醇和孕酮均敏感的细胞以及仅对孕酮敏感的细胞。描述了一种细胞类型转变为另一种细胞类型所需的条件以及每种细胞类型的组织化学特征。该模型已用于分析子宫内膜增生过程和癌症中发生的形态学变化，以及为这些疾病的当前激素治疗方案提供依据。
