霉菌毒素桔霉素对小鼠某些激素以及糖酵解途径中酶和底物的影响。

Effect of the mycotoxin citrinin on some hormones and on enzymes and substrates of the Embden-Meyerhof pathway in mice.

作者信息

Gupta M, Dolui A K, Dey S N, Mukherjee S, Majumder U K, Batabyal S K

出版信息

Toxicon. 1986;24(5):519-23. doi: 10.1016/0041-0101(86)90086-3.

Abstract

The effects of six weeks treatment with multiple i.p. doses of citrinin (15, 25 and 35 mg/kg) on some hormonal activities and on enzymes and substrates of the Embden--Meyerhof pathway in mice were studied. Adenosine triphosphatase, hexokinase, lactate dehydrogenase, lactic acid and pyruvic acid decreased in blood, liver, kidney and brain of citrinin-treated mice. Glucose levels in blood, kidney and brain increased and glycogen content of liver decreased. Cortisol, triiodothyronine and thyroxine levels of serum increased, but insulin levels decreased.

摘要

研究了多次腹腔注射不同剂量（15、25和35毫克/千克）桔霉素对小鼠进行六周治疗后，对某些激素活性以及糖酵解途径中酶和底物的影响。在接受桔霉素治疗的小鼠的血液、肝脏、肾脏和大脑中，三磷酸腺苷酶、己糖激酶、乳酸脱氢酶、乳酸和丙酮酸含量均有所下降。血液、肾脏和大脑中的葡萄糖水平升高，肝脏中的糖原含量降低。血清中的皮质醇、三碘甲状腺原氨酸和甲状腺素水平升高，但胰岛素水平降低。