Department of Pharmaceutics, School of Pharmacy, Air Force Medical University, Changle West Road 169, Xi'an, 710032, Shaanxi, China.
Department of Pharmaceutics, School of Pharmacy, Air Force Medical University, Changle West Road 169, Xi'an, 710032, Shaanxi, China.
Redox Biol. 2023 Jul;63:102734. doi: 10.1016/j.redox.2023.102734. Epub 2023 May 6.
Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, and its early onset is closely related to mitochondrial energy metabolism. The brain is only 2% of body weight, but consumes 20% of total energy needs. Mitochondria are responsible for providing energy in cells, and maintaining their homeostasis ensures an adequate supply of energy to the brain. Mitochondrial homeostasis is constituted by mitochondrial quantity and quality control, which is dynamically regulated by mitochondrial energy metabolism, mitochondrial dynamics and mitochondrial quality control. Impaired energy metabolism of brain cells occurs early in AD, and maintaining mitochondrial homeostasis is a promising therapeutic target in the future. We summarized the mechanism of mitochondrial homeostasis in AD, its influence on the pathogenesis of early AD, strategies for maintaining mitochondrial homeostasis, and mitochondrial targeting strategies. This review concludes with the authors' opinions on future research and development for mitochondrial homeostasis of early AD.
阿尔茨海默病（AD）是最常见的神经退行性疾病之一，其早期发病与线粒体能量代谢密切相关。大脑仅占体重的 2%，却消耗了全身总能量需求的 20%。线粒体负责为细胞提供能量，维持其动态平衡以确保大脑有充足的能量供应。线粒体的动态平衡由线粒体的数量和质量控制构成，这是由线粒体能量代谢、线粒体动力学和线粒体质量控制来动态调节的。在 AD 中，脑细胞的能量代谢很早就出现了损伤，维持线粒体的动态平衡是未来有前景的治疗靶点。我们总结了 AD 中线粒体动态平衡的机制，它对早期 AD 发病机制的影响，维持线粒体动态平衡的策略，以及线粒体靶向策略。本文以作者对早期 AD 中线粒体动态平衡的未来研究和发展的观点作为总结。
