Tauber A, Petrowicz O, Tauber R, Wriedt-Lübbe I, Schneider R, Blümel G, Kolb E
Infusionsther Klin Ernahr. 1979 Jun;6(3):195-200.
70 rats were subjected to tourniquet ischemia of a hind limb for a period of two and three hours. 12 rats served as controls. After release of the 3 hours tourniquets 20 rats were treated either with Ringer's solution or with hydroxyethyl starch. Kidney function and morphology, systolic blood pressure, hematocrit, serum electrolytes, creatinine and urea were studied as different times of recirculation. 1. Reduction in renal function was only observed after releasing the tourniquets. 2. The extent of reduction in renal function depended on the time of ischemia and time of recirculation. 3 hours of tourniquet with two hours of recirculation led to the largest extent of reduction in renal function and renal parenchymal lesions. 3. If the infusion of HES was applied at the beginning of recirculation, reduction in renal function was prevented, as well as parenchymal lesions. Ringer's infusion, however, did not improve kidney function to a normal range.
70只大鼠后肢接受了2至3小时的止血带缺血处理。12只大鼠作为对照。在松开3小时的止血带后，20只大鼠分别接受林格氏液或羟乙基淀粉治疗。在再灌注的不同时间点研究了肾功能和形态、收缩压、血细胞比容、血清电解质、肌酐和尿素。1. 仅在松开止血带后观察到肾功能下降。2. 肾功能下降的程度取决于缺血时间和再灌注时间。3小时止血带缺血并再灌注2小时导致肾功能下降和肾实质损伤的程度最大。3. 如果在再灌注开始时输注羟乙基淀粉，则可预防肾功能下降以及实质损伤。然而，输注林格氏液并不能使肾功能恢复到正常范围。
