Division of Endocrinology, Diabetes & Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.
Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.
Dev Cell. 2023 May 8;58(9):725-726. doi: 10.1016/j.devcel.2023.04.008.
In this issue of Developmental Cell, Zhu et al. provide integrated data from single-cell/nuclei RNAseq and chromatin accessibility (ATAC) across both a multistaged differentiation protocol-deriving pancreatic islets from hESCs and primary islets. This important resource could be leveraged for optimizing the differentiation and maturation of pancreatic islet cells from hESCs.
在本期《发育细胞》中，Zhu 等人提供了源自 hESC 的多阶段分化方案和原代胰岛的单细胞/核 RNAseq 和染色质可及性 (ATAC) 的综合数据。这个重要的资源可以用于优化从 hESC 分化和成熟胰岛细胞。
