利用单细胞多推断调控组改善干细胞衍生的胰岛。

Improving stem cell-derived pancreatic islets using single-cell multi-inferred regulomes.

机构信息

Division of Endocrinology, Diabetes & Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.

Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA.

出版信息

Dev Cell. 2023 May 8;58(9):725-726. doi: 10.1016/j.devcel.2023.04.008.

DOI:10.1016/j.devcel.2023.04.008

PMID:37160100

Abstract

In this issue of Developmental Cell, Zhu et al. provide integrated data from single-cell/nuclei RNAseq and chromatin accessibility (ATAC) across both a multistaged differentiation protocol-deriving pancreatic islets from hESCs and primary islets. This important resource could be leveraged for optimizing the differentiation and maturation of pancreatic islet cells from hESCs.

摘要

在本期《发育细胞》中，Zhu 等人提供了源自 hESC 的多阶段分化方案和原代胰岛的单细胞/核 RNAseq 和染色质可及性 (ATAC) 的综合数据。这个重要的资源可以用于优化从 hESC 分化和成熟胰岛细胞。