Nutrition and Exercise Metabolism Research Group, Food and Nutrition Institute, Multidisciplinary Center UFRJ-Macaé, Rio de Janeiro, Brazil.
Graduate Program in Bioactive Products and Biosciences, Multidisciplinary Center UFRJ-Macaé, Rio de Janeiro, Brazil.
Int J Food Sci Nutr. 2023 May;74(3):373-381. doi: 10.1080/09637486.2023.2207783. Epub 2023 May 9.
In the present study, it was evaluated whether microencapsulated cocoa supplementation could attenuate endothelial dysfunction caused by eccentric exercise in healthy subjects. Thirteen volunteers were enrolled in this double-blind, placebo-controlled, crossover study. Flow-mediated dilatation (FMD), blood flow and muscle O saturation (StO) were evaluated by ultrasound and near-infrared spectroscopy (NIRS), respectively, before and after microencapsulated cocoa supplementation. The eccentric exercise was performed after microencapsulated cocoa supplementation to generate vascular dysfunction. Eccentric exercise significantly reduced FMD in the PLA condition, but cocoa attenuated this exercise effect. No significant effect was observed on muscle StO and blood flow after eccentric exercise and nutritional supplementation. In conclusion, the present study showed that a single dose of microencapsulated cocoa ingestion attenuated FMD-induced eccentric exercise. These findings suggest that a single dose of microencapsulated cocoa may be an alternative nutritional strategy to attenuate vascular dysfunction induced by eccentric exercise in healthy individuals.
在本研究中，评估了微囊化可可补充剂是否可以减轻健康受试者离心运动引起的血管内皮功能障碍。13 名志愿者参与了这项双盲、安慰剂对照、交叉研究。在微囊化可可补充前后，分别通过超声和近红外光谱（NIRS）评估血流介导的扩张（FMD）、血流和肌肉氧饱和度（StO）。在微囊化可可补充后进行离心运动以产生血管功能障碍。PLA 条件下的离心运动显著降低了 FMD，但可可减轻了这种运动的效果。离心运动和营养补充后，肌肉 StO 和血流没有观察到显著影响。总之，本研究表明，单次摄入微囊化可可可减轻离心运动引起的 FMD 降低。这些发现表明，单次摄入微囊化可可可能是一种替代的营养策略，可以减轻健康个体离心运动引起的血管功能障碍。
