Department of Orthopedic Surgery, Hokkaido University Graduate School of Medicine, Kita-15 Nishi-7, Kita-ku, Sapporo, Hokkaido 060-8638, Japan; Department of Orthopedics, Hakodate Central General Hospital, 33-2 Hon-cho, Hakodate, Hokkaido 040-8585, Japan.
Department of Orthopedic Surgery, Hokkaido University Graduate School of Medicine, Kita-15 Nishi-7, Kita-ku, Sapporo, Hokkaido 060-8638, Japan; Department of Orthopedics, Hakodate Central General Hospital, 33-2 Hon-cho, Hakodate, Hokkaido 040-8585, Japan.
Spine J. 2023 Sep;23(9):1287-1295. doi: 10.1016/j.spinee.2023.05.005. Epub 2023 May 7.
Obesity and visceral fat have been implicated as potential factors in the pathogenesis of the ossification of the posterior longitudinal ligament (OPLL); the details of the factors involved in OPLL remain unclear.
We aimed to determine the association between dyslipidemia and symptomatic OPLL.
Single institution cross-sectional study.
Data were collected from Japanese patients with OPLL (n=92) who underwent whole-spine computed tomography scanning. Control data (n=246) without any spinal ligament ossification were collected from 627 Japanese participants who underwent physical examination.
Baseline information and lipid parameters, including triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) from fasting blood samples were collected to assess the comorbidity of dyslipidemia.
Patient data were collected from 2020 to 2022. Patients with dyslipidemia were defined as those who were taking medication for dyslipidemia and who met one of the following criteria: TG ≥150 mg/dL, LDL-C ≥140 mg/dL, and/or HDL-C <40 mg/dL. The factors associated with OPLL development were evaluated using multivariate logistic regression analysis.
The comorbidity of dyslipidemia in the OPLL group was more than twice that in the control group (71.7% and 35.4%, respectively). The mean body mass index (BMI) of the OPLL group was significantly higher than that of the control group (27.2 kg/m and 23.0 kg/m). Multivariate logistic regression analysis revealed that dyslipidemia was associated with the development of OPLL (regression coefficient, 0.80; 95% confidence interval, 0.11-1.50). Additional risk factors included age, BMI, and diabetes mellitus.
We demonstrated a novel association between dyslipidemia and symptomatic OPLL development using serum data. This suggests that visceral fat obesity or abnormal lipid metabolism are associated with the mechanisms of onset and exacerbation of OPLL as well as focal mechanical irritation due to being overweight.
肥胖和内脏脂肪被认为是后纵韧带骨化症（OPLL）发病机制中的潜在因素；但 OPLL 涉及的具体因素仍不清楚。
本研究旨在确定血脂异常与症状性 OPLL 之间的关系。
单机构横断面研究。
数据来自 92 例接受全脊柱计算机断层扫描的 OPLL 日本患者。对照组数据（n=246）来自 627 名接受体检的日本参与者，他们没有任何脊柱韧带骨化。
从空腹血样中收集基线信息和血脂参数，包括甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C），以评估血脂异常的合并症。
患者数据收集于 2020 年至 2022 年。血脂异常患者定义为正在服用降脂药物且符合以下标准之一的患者：TG≥150mg/dL、LDL-C≥140mg/dL 和/或 HDL-C<40mg/dL。采用多变量 logistic 回归分析评估与 OPLL 发展相关的因素。
OPLL 组血脂异常的合并症发生率是对照组的两倍多（分别为 71.7%和 35.4%）。OPLL 组的平均体重指数（BMI）显著高于对照组（27.2kg/m和 23.0kg/m）。多变量 logistic 回归分析显示，血脂异常与 OPLL 的发生相关（回归系数，0.80；95%置信区间，0.11-1.50）。其他危险因素包括年龄、BMI 和糖尿病。
本研究使用血清数据证实了血脂异常与症状性 OPLL 发展之间存在新的关联。这表明内脏脂肪肥胖或脂质代谢异常与 OPLL 的发病机制和加重以及超重导致的局部机械刺激有关。
