帕金森病中与时间频率相关的视觉诱发电位变化

Temporal frequency-dependent VEP changes in Parkinson's disease.

作者信息

Marx M, Bodis-Wollner I, Bobak P, Harnois C, Mylin L, Yahr M

出版信息

Vision Res. 1986;26(1):185-93. doi: 10.1016/0042-6989(86)90080-5.

Abstract

We recorded steady-state (4.19 and 8.41 Hz) VEPs in 17 Parkinson's Disease (PD) patients and 18 control observers using on-off temporal modulation of a 2.3 c/deg sinusoidal grating. With 4.19 Hz, 20 out of 33 PD patient eyes had abnormal VEPs. However, only 8 of 33 eyes were abnormal with 8.41 Hz. "Routine" (counterphase) transient VEPs revealed delayed VEPs for only 7 out of 24 eyes of the patients. These findings suggest an "input" temporal frequency-dependent abnormality in the foveal pathway.

摘要

我们使用2.3 c/deg正弦光栅的开-关时间调制，记录了17名帕金森病（PD）患者和18名对照观察者的稳态（4.19和8.41 Hz）视觉诱发电位（VEP）。在4.19 Hz时，33只PD患者眼中有20只VEP异常。然而，在8.41 Hz时，33只眼中只有8只异常。“常规”（反相）瞬态VEP显示，患者24只眼中只有7只VEP延迟。这些发现提示中央凹通路存在“输入”时间频率依赖性异常。