Kanaev S V, Kholin A V, Malinin A P
Vopr Onkol. 1986;32(5):50-4.
Data on 314 cases of radiation and chemoradiation treatment for Hodgkin's disease were analysed. Pulmonitis was registered in 8.9 and paramediastinal fibrosis--in 37.6%. The incidence of pulmonitis did not vary with cumulative radiation effect (CRE) and time-dose-fraction (TDF) values computed for irradiation field area. A significant increase in the incidence of paramediastinal fibrosis was observed at CRE and TDF values exceeding 1,500 reu and 77 units, respectively. There was no relationship between the above pathology and treatment modality (60Co teletherapy and 25 MeV fast electrons).
对314例霍奇金病的放疗和放化疗病例数据进行了分析。肺炎的发生率为8.9%，纵隔旁纤维化的发生率为37.6%。肺炎的发生率与针对照射野面积计算的累积辐射效应（CRE）和时间-剂量-分次（TDF）值无关。当CRE和TDF值分别超过1500雷姆当量单位和77单位时，纵隔旁纤维化的发生率显著增加。上述病理情况与治疗方式（60钴远距离治疗和25兆电子伏快速电子）之间没有关系。
