极低出生体重早产儿呼吸严重程度评分与支气管肺发育不良相关肺动脉高压的关联
Association of the Respiratory Severity Score with Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension in Infants Born Extremely Preterm.
作者信息
Kielt Matthew, Beer Lindsey, Rivera Brian, Jama Waceys, Slaughter Jonathan, Backes Carl, Conroy Sara
机构信息
Nationwide Children's Hospital, The Ohio State University College of Medicine.
Nationwide Children's Hospital.
出版信息
Res Sq. 2023 Apr 27:rs.3.rs-2852392. doi: 10.21203/rs.3.rs-2852392/v1.
OBJECTIVE
To test the hypothesis that elevations in the respiratory severity score (RSS) are associated with increased risk of bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH).
STUDY DESIGN
Retrospective cohort study of infants born extremely preterm admitted to a BPD center between 2010-2018. Echocardiograms obtained ≥36 weeks' post-menstrual age (PMA) were independently adjudicated by two blinded cardiologists to determine the presence/absence of BPD-PH. Multivariable logistic regression estimated the association between RSS with BPD-PH.
RESULT
BPD-PH was observed in 68/223 (36%) of subjects. The median RSS at time of echocardiography was 3.04 (Range 0-18.3). A one-point increase in RSS was associated with BPD-PH, aOR 1.3 (95% CI 1.2-1.4), after adjustment for gestational age and PMA at time of echocardiography.
CONCLUSION
Elevations in the RSS were associated with a greater risk of BPD-PH. Prospective studies are needed to determine the validity and performance of RSS as a clinical susceptibility/risk biomarker for BPD-PH.
目的
检验呼吸严重程度评分（RSS）升高与支气管肺发育不良相关肺动脉高压（BPD-PH）风险增加相关的假设。
研究设计
对2010年至2018年间入住一家BPD中心的极早产儿进行回顾性队列研究。由两名 blinded 心脏病专家独立判定在月经龄（PMA）≥36周时获得的超声心动图，以确定是否存在BPD-PH。多变量逻辑回归估计RSS与BPD-PH之间的关联。
结果
68/223（36%）的受试者观察到BPD-PH。超声心动图检查时的RSS中位数为3.04（范围0-18.3）。在调整超声心动图检查时的胎龄和PMA后，RSS每增加1分与BPD-PH相关，调整后比值比为1.3（95%置信区间1.2-1.4）。
结论
RSS升高与BPD-PH风险增加相关。需要进行前瞻性研究以确定RSS作为BPD-PH临床易感性/风险生物标志物的有效性和性能。
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