Ohio Perinatal Research Network, Nationwide Children's Hospital, Columbus, OH, USA.
Division of Neonatology, Nationwide Children's Hospital, Columbus, OH, USA.
J Perinatol. 2024 Feb;44(2):294-300. doi: 10.1038/s41372-023-01798-y. Epub 2023 Oct 18.
To test the hypothesis that elevations in the respiratory severity score (RSS) are associated with increased probability of bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH).
Retrospective cohort study of infants born extremely preterm admitted to a BPD center between 2010 and 2018. Echocardiograms obtained ≥ 36 weeks' post-menstrual age (PMA) were independently adjudicated by two blinded cardiologists to determine the presence/absence of BPD-PH. Multivariable logistic regression estimated the association between RSS and BPD-PH.
BPD-PH was observed in 68/223 (36%) of subjects. The median RSS at time of echocardiography was 3.04 (Range 0-18.3). A one-point increase in the RSS was associated with BPD-PH, aOR 1.3 (95% CI 1.2-1.4), after adjustment for gestational age and PMA at time of echocardiography.
Elevations in the RSS were associated with a greater probability of BPD-PH. Prospective studies are needed to determine the validity and performance of RSS as a clinical susceptibility/risk biomarker for BPD-PH.
验证 RSS 升高与 BPD-PH 发生概率增加相关的假设。
对 2010 年至 2018 年间在 BPD 中心出生的极早产儿进行回顾性队列研究。≥36 周校正胎龄（PMA）时获得的超声心动图由两名盲法心脏病专家独立判断，以确定是否存在 BPD-PH。多变量逻辑回归估计 RSS 与 BPD-PH 之间的关联。
223 例中有 68 例（36%）发生 BPD-PH。超声心动图时的 RSS 中位数为 3.04（范围 0-18.3）。调整胎龄和超声心动图时的 PMA 后，RSS 每增加 1 分，BPD-PH 的优势比为 1.3（95%CI 1.2-1.4）。
RSS 升高与 BPD-PH 的发生概率增加相关。需要前瞻性研究来确定 RSS 作为 BPD-PH 的临床易感性/风险生物标志物的有效性和性能。
