School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences, Dublin, Ireland.
Data Science Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Br J Clin Pharmacol. 2023 Aug;89(8):2349-2358. doi: 10.1111/bcp.15779. Epub 2023 May 31.
In 2017, two distinct interventions were implemented in Ireland and England to reduce prescribing of lidocaine medicated plasters. In Ireland, restrictions on reimbursement were introduced through implementation of an application system for reimbursement. In England, updated guidance on items which should not be routinely prescribed in primary care, including lidocaine plasters, was published. This study aims to compare how the interventions impacted prescribing of lidocaine plasters in these countries.
We conducted an interrupted time-series study using general practice data. For Ireland, monthly dispensing data (2015-2019) from the means-tested General Medical Services (GMS) scheme was used. For England, data covered all patients. Outcomes were the rate of dispensings, quantity and costs of lidocaine plasters, and we modelled level and trend changes from the first full month of the policy/guidance change.
Ireland had higher rates of lidocaine dispensings compared to England throughout the study period; this was 15.22/1000 population immediately pre-intervention, and there was equivalent to a 97.2% immediate reduction following the intervention. In England, the immediate pre-intervention dispensing rate was 0.36/1000, with an immediate reduction of 0.0251/1000 (a 5.8% decrease), followed by a small but significant decrease in the monthly trend relative to the pre-intervention trend of 0.0057 per month.
Among two different interventions aiming to decrease low-value lidocaine plaster prescribing, there was a substantially larger impact in Ireland of reimbursement restriction compared to issuing guidance in England. However, this is in the context of much higher baseline rates of use in Ireland compared to England.
2017 年,爱尔兰和英国实施了两项不同的干预措施,以减少利多卡因贴膏的处方。在爱尔兰,通过实施报销申请系统,对报销进行了限制。在英国,发布了关于不应在初级保健中常规开具的项目的更新指南,包括利多卡因贴膏。本研究旨在比较这两项干预措施对这两个国家利多卡因贴膏处方的影响。
我们使用一般实践数据进行了一项中断时间序列研究。对于爱尔兰,使用了基于经济状况调查的普通医疗服务(GMS)计划的每月配药数据(2015-2019 年)。对于英国,数据涵盖了所有患者。结果是利多卡因贴膏的配药率、数量和成本,并对政策/指南变更的第一个完整月份进行了水平和趋势变化建模。
在整个研究期间,爱尔兰的利多卡因配药率均高于英国;这是干预前的 15.22/1000 人口,干预后立即减少了 97.2%。在英国,干预前的配药率为 0.36/1000,立即减少了 0.0251/1000(减少了 5.8%),随后与干预前趋势相比,每月趋势呈小幅但显著下降,每月下降 0.0057。
在两项旨在减少低价值利多卡因贴膏处方的不同干预措施中,与在英国发布指南相比,爱尔兰的报销限制对处方的影响要大得多。然而,这是在爱尔兰的使用基线率明显高于英国的背景下。