Laboratory of Clinical Nutrition and Management, Graduate Division of Nutritional and Environmental Sciences, and Graduate School of Integrated Pharmaceutical and Nutritional Sciences, The University of Shizuoka, Shizuoka, Japan.
These authors contributed equally to this work.
J Med Invest. 2023;70(1.2):34-40. doi: 10.2152/jmi.70.34.
In Japan, hyperuricemia is on the rise. The guideline for the management of hyperuricemia and gout recommends lifestyle changes before beginning drug therapy. This study aimed to evaluate the effectiveness of dietary counseling following the guideline. Thirty-three subjects (24 men and 9 women) with asymptomatic hyperuricemia underwent dietary counseling for 6 months based on the following recommendations : (1) prevent excessive purine intake, (2) prevent excessive fructose intake, (3) limit alcohol drinking, and (4) drink sufficient water. Obese subjects were counseled on adequate energy intake. Blood sampling, anthropometric measurements, dietary surveys, and 24-h urine collection were performed at baseline and at 6 months. Serum uric acid (S-UA) levels were significantly lower at 6 months compared to baseline. Water intake and urine volume were considerably higher at 6 months than at baseline. When compared to baseline, urine UA (U-UA) levels were significantly lower, and renal fractional excretion of UA (FEUA) was significantly higher at 6 months. Changes in renal function (serum creatinine, estimated glomerular filtration rate, and FEUA) were significantly associated with ?S-UA level. In this study, S-UA level was significantly decreased by dietary counseling in line with the guideline. This study illustrates the effectiveness of dietary counseling for asymptomatic hyperuricemia. J. Med. Invest. 70 : 34-40, February, 2023.
在日本，高尿酸血症的发病率呈上升趋势。高尿酸血症和痛风管理指南建议在开始药物治疗前进行生活方式改变。本研究旨在评估遵循该指南进行饮食咨询的效果。33 名（24 名男性和 9 名女性）无症状高尿酸血症患者接受了 6 个月的饮食咨询，建议如下：（1）预防嘌呤摄入过多，（2）预防果糖摄入过多，（3）限制饮酒，（4）多喝水。肥胖患者应进行适当的能量摄入咨询。在基线和 6 个月时进行血液采样、人体测量、膳食调查和 24 小时尿液收集。与基线相比，6 个月时血清尿酸（S-UA）水平显著降低。与基线相比，6 个月时水摄入量和尿量明显增加。与基线相比，6 个月时尿 UA（U-UA）水平显著降低，UA 的肾分数排泄（FEUA）显著升高。肾功能（血清肌酐、估计肾小球滤过率和 FEUA）的变化与 S-UA 水平显著相关。在这项研究中，饮食咨询按照指南显著降低了 S-UA 水平。本研究说明了饮食咨询对无症状高尿酸血症的有效性。医学研究杂志 70：34-40，2023 年 2 月。
