Department of Pediatrics, Yaizu City Hospital.
Department of Pediatrics, The University of Tokyo Hospital.
Fukushima J Med Sci. 2023 Aug 10;69(2):115-123. doi: 10.5387/fms.2022-21. Epub 2023 May 11.
The risk factors for anemia of prematurity (AOP) among late preterm infants are unelucidated. We identified risk factors for declining hemoglobin (Hb) concentration and triggering factors for AOP treatment in infants born at 30-35 gestational weeks.
From 2012 to 2020, we conducted a single-center retrospective study of infants born at 30-35 weeks of gestation without congenital anomalies or severe hemorrhage. The primary outcome was AOP development, defined by initiation of treatments including red blood cell transfusion, subcutaneous injections of erythropoietin, and iron supplementation. A multivariable logistic regression model was used to investigate potential risk factors for AOP.
A total of 358 infants were included. Lower gestational age (odds ratio, 0.19; 95% confidence interval 0.11-0.32), small for gestational age (SGA; 7.17, 2.15-23.9), low maternal Hb level before birth (0.66, 0.49-0.87), low Hb at birth (0.71, 0.57-0.89), and multiple large blood samplings (1.79; 1.40-2.29) showed significantly higher odds for AOP development.
Gestational age, SGA, low maternal Hb before birth, Hb at birth, and high number of large blood samplings were positively associated with AOP development in infants born at 30-35 gestational weeks.
早产儿贫血（AOP）的风险因素仍不明确。我们确定了胎龄 30-35 周的婴儿血红蛋白（Hb）浓度下降的风险因素和触发 AOP 治疗的因素。
我们进行了一项单中心回顾性研究，纳入了 2012 年至 2020 年间出生胎龄 30-35 周且无先天性异常或严重出血的婴儿。主要结局是 AOP 发展，通过开始输血、皮下注射促红细胞生成素和铁补充等治疗来定义。使用多变量逻辑回归模型来研究 AOP 的潜在风险因素。
共纳入 358 名婴儿。较低的胎龄（比值比，0.19；95%置信区间 0.11-0.32）、小于胎龄儿（SGA；7.17，2.15-23.9）、出生前母亲 Hb 水平低（0.66，0.49-0.87）、出生时 Hb 水平低（0.71，0.57-0.89）和多次大采血（1.79；1.40-2.29）与 AOP 发展的几率显著升高相关。
胎龄、SGA、出生前母亲 Hb 水平低、出生时 Hb 水平低和大采血次数多与胎龄 30-35 周的婴儿 AOP 发展呈正相关。
