rs963549 和 rs997917 多态性与阿片类药物使用障碍及相关表型的关联。
Association of rs963549 and rs997917 polymorphisms with opioid use disorder and related phenotypes.
机构信息
Kırşehir Ahi Evran University, Faculty of Science & Art, Department of Molecular Biology & Genetics, Kırşehir, Türkiye.
Ankara University, Institute of Forensic Sciences, Ankara, 06590, Türkiye.
出版信息
Pharmacogenomics. 2023 Apr;24(6):325-334. doi: 10.2217/pgs-2023-0037. Epub 2023 May 11.
To evaluate the association between rs963549 and rs997917 and opioid use disorder (OUD) and related phenotypes. A sample of 208 individuals with (n = 100) and without (n = 108) OUD were enrolled. rs963549 and rs997917 were analyzed by PCR-RFLP. Craving, opioid withdrawal and the intensity of depressive and anxiety symptoms were measured by the appropriate scales. rs963549 variation showed a trend of association with decreased opioid withdrawal. No significant associations were found between rs963549 and rs997917 polymorphisms and craving, depression or anxiety symptoms. Neither single SNPs nor haplotypes were associated with OUD. Our results could be useful for treatment failures of individuals who experience greater opioid withdrawal due to their rs963549 genotypes.
评估 rs963549 和 rs997917 与阿片类药物使用障碍 (OUD) 及相关表型的关联。招募了 208 名个体，其中包括 100 名（n=100）和 108 名（n=108）无 OUD。通过 PCR-RFLP 分析 rs963549 和 rs997917。通过适当的量表测量成瘾、阿片类药物戒断以及抑郁和焦虑症状的强度。rs963549 变异与阿片类药物戒断减少呈趋势关联。rs963549 和 rs997917 多态性与成瘾、抑郁或焦虑症状之间没有显著关联。单个 SNP 或单倍型均与 OUD 无关。我们的结果可能对因 rs963549 基因型而经历更大阿片类药物戒断的个体的治疗失败有用。
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