Department of Dermatology, Hangzhou Third People's Hospital, Zhejiang Chinese Medical University, Hangzhou, China.
Department of Dermatology, Affiliated Hangzhou Dermatology Hospital, Hangzhou Third People's Hospital, Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University, Zhejiang University School of Medicine, Hangzhou, China -
Ital J Dermatol Venerol. 2023 Jun;158(3):236-242. doi: 10.23736/S2784-8671.23.07499-6. Epub 2023 May 11.
Facial erythema can be seen in many patients. Despite various clinical trials exploring the effect of intense pulsed light (IPL) in treating facial erythema, comprehensive evidence about the specific outcomes remains lacking.
We searched published studies in the Web of Science, PubMed, Embase, and Cochrane Library databases based on established inclusion criteria. We calculated odds ratios (OR) to evaluate the effectiveness of IPL in patients with facial erythema. We used Review Manager 5.4.1 software for statistical data analyses with a 95% confidence interval (CI).
This review includes seven studies with 219 patients, of which five compared the efficacy of IPL with pulsed dye laser (PDL). IPL significantly improved facial erythema compared to no treatment (OR=56.64, 95% CI: 22.70-141.33; P<0.00001). However, there was no significant difference between IPL and PDL treatment (OR=1.00, 95% CI: 0.31-3.22; P=1.00). Moreover, there was no significant difference in patients with a >50% reduction in telangiectasias between IPL and PDL treatment (OR=1.00, 95% CI: 0.39-2.56; P=1.00). Furthermore, IPL therapy had no apparent adverse effects for most people besides transitory edema and erythema.
Our meta-analysis indicated that IPL could effectively and safely improve facial erythema with similar efficacy to PDL. Based on its comprehensive function, light side effects, and long curative effect, IPL appears to be a good alternative for treating facial erythema. However, further prospective and high-quality studies are required.
许多患者都会出现面部红斑。尽管有多项临床试验探索了强脉冲光（IPL）治疗面部红斑的效果，但仍缺乏关于具体结果的综合证据。
我们根据既定纳入标准，在 Web of Science、PubMed、Embase 和 Cochrane Library 数据库中搜索了已发表的研究。我们计算了比值比（OR）来评估 IPL 治疗面部红斑患者的效果。我们使用 Review Manager 5.4.1 软件进行统计数据分析，置信区间为 95%。
本综述共纳入 7 项研究，共 219 例患者，其中 5 项研究比较了 IPL 和脉冲染料激光（PDL）的疗效。与未治疗相比，IPL 可显著改善面部红斑（OR=56.64，95%CI：22.70-141.33；P<0.00001）。然而，IPL 与 PDL 治疗之间无显著差异（OR=1.00，95%CI：0.31-3.22；P=1.00）。此外，IPL 和 PDL 治疗后，毛细血管扩张减少>50%的患者之间也无显著差异（OR=1.00，95%CI：0.39-2.56；P=1.00）。此外，大多数人除了短暂的水肿和红斑外，IPL 治疗没有明显的不良反应。
我们的荟萃分析表明，IPL 可有效且安全地改善面部红斑，疗效与 PDL 相当。基于其综合功能、轻度副作用和持久疗效，IPL 似乎是治疗面部红斑的一种较好的选择。然而，还需要进一步进行前瞻性和高质量的研究。
