1Tbilisi State Medical University, Georgia.
4P. Sarajishvili Institute of Neurology, Tbilisi, Georgia.
Georgian Med News. 2023 Mar(336):91-94.
Objective - to identify risk factors in patients diagnosed with Amyotrophic Lateral Sclerosis in Georgia directed to The First University Clinic of TSMU and P. Sarajishvili Institute of Neurology. Totally 53 patients, aged 24 to 82 years, were investigated with Amyotrophic Lateral Sclerosis (ALS), defined by "Gold Coast " criteria. We have used the Questionnaire for Environmental Exposures, Toxins, and Neurological diseases developed by Dartmouth-Hitchcock Medical center to identify risk factors, and categorized patients according to the place of settlement and environmental hazards. The control consisted of age and sex matched 50 healthy individuals. The brain was visualized by MRI (1.5T), and Electromyography (EMG) was performed on all patients. ALS risk was higher among those ever holding a job in mechanics, painting, or construction (p<0.05), head trauma or concussion that caused a "blackout" or loss of consciousness was associated with a higher risk of ALS (p<0.01). Demographically more ALS cases were found in Tbilisi and Imereti, compared to other regions (p<0.05). According to our research on Georgian ALS cases, several occupational jobs, Head trauma is associated with developing ALS in Georgia, Research is needed to identify environmental risk factors attributing to higher rates of ALS in Tbilisi and Imereti.
目的 - 确定在格鲁吉亚被诊断为肌萎缩侧索硬化症（ALS）的患者的风险因素，这些患者被送往 TSMU 的第一大学诊所和 P. Sarajishvili 神经病学研究所。共有 53 名年龄在 24 至 82 岁之间的患者被诊断为肌萎缩侧索硬化症（ALS），这些患者符合“黄金海岸”标准。我们使用了由达特茅斯-希区柯克医疗中心开发的环境暴露、毒素和神经疾病问卷来确定风险因素，并根据居住地点和环境危害对患者进行分类。对照组由年龄和性别匹配的 50 名健康个体组成。所有患者均进行了 MRI（1.5T）检查和肌电图（EMG）检查。在机械、绘画或建筑行业工作过的患者（p<0.05），或头部创伤或脑震荡导致“昏厥”或失去意识的患者（p<0.01），患 ALS 的风险更高。与其他地区相比，在第比利斯和伊梅列季地区发现了更多的 ALS 病例（p<0.05）。根据我们对格鲁吉亚 ALS 病例的研究，一些职业工作、头部创伤与格鲁吉亚 ALS 的发病有关，需要研究确定导致第比利斯和伊梅列季 ALS 发病率较高的环境风险因素。
