Korkina M V, Tsivil'ko M A, Zaĭtseva Zh F, Kareva M A
Zh Nevropatol Psikhiatr Im S S Korsakova. 1986;86(4):556-61.
On the basis of the clinical, experimental-psychological and electroencephalographic examinations of 173 patients with portal hypertension (intrahepatic--110 and extrahepatic--63) the authors elucidated the regularities of the formation of mental disorders, their clinical characteristics and the course following surgical treatment. The asthenic syndrome with marked vegetative disturbances was the most prominent feature in the clinical picture. Patients with hepatic cirrhosis were characterized by a more severe asthenia and greater intensity of vegetative symptomatology as compared to patients with an extrahepatic form of portal hypertension. Characteristic of psychotic disorders in liver cirrhosis was severity of the psychoorganic syndrome. Personality shifts with the predominance of explosiveness, epilepsy- and paranoia-like tendencies grow with disease progression. Surgical treatment by constructing vascular anastomoses occasionally leads to intensification of the psychoorganic syndrome in cirrhosis patients and to its appearance in patients with extrahepatic portal hypertension, which calls for the development of more clear-cut indications for such surgery.
基于对173例门静脉高压患者(肝内型110例,肝外型63例)的临床、实验心理学和脑电图检查,作者阐明了精神障碍的形成规律、临床特征以及手术治疗后的病程。临床症状中最突出的特征是伴有明显自主神经功能紊乱的虚弱综合征。与肝外型门静脉高压患者相比,肝硬化患者的虚弱症状更严重,自主神经症状更明显。肝硬化患者精神障碍的特征是精神器质性综合征严重。随着疾病进展,以易激惹、癫痫样和偏执样倾向为主的人格改变会加重。通过构建血管吻合术进行手术治疗偶尔会导致肝硬化患者精神器质性综合征加重,并使肝外型门静脉高压患者出现该综合征,这就需要为这种手术制定更明确的适应证。