From the College of Veterinary Medicine, University of Florida, Gainesville, Florida (J.W., C.S.); and the United States Army, San Antonio, Texas (L.H.).
J Am Anim Hosp Assoc. 2023 May 1;59(3):152-157. doi: 10.5326/JAAHA-MS-7348.
Manganese is a common component of human joint supplements and may be a source of ingestion and subsequent toxicosis in dogs. Although hepatotoxicity secondary to manganese toxicosis has been reported in dogs before, no descriptions of successful management of manganese toxicosis has been reported in veterinary literature. A 5 yr old spayed female Shetland sheepdog and a 5 yr old female Shetland sheepdog were evaluated following accidental ingestion of a joint supplement. Consultation with a toxicologist revealed concern for manganese toxicosis resulting in hepatic injury. Both dogs developed subsequent acute liver injury, despite decontamination and initial management with N-acetylcysteine and cholestyramine. The patients were managed with calcium ethylenediaminetetraacetic acid, paraaminosalicylic acid, allopurinol, Vitamin E, ginkgo biloba, and S-adenosylmethionine/silybin. Liver values returned to normal in both dogs. Manganese exposure was confirmed with urine manganese analysis in one dog and fecal examination in the other dog. A previous case report detailed the fatal manganese toxicosis in a dog; this case report describes the successful management of severe acute hepatic injury secondary to manganese toxicosis. The combination of medications used above may be used for successful treatment of manganese toxicosis in dogs.
锰是一种常见的关节补充剂成分，可能是犬类摄入和随后发生中毒的来源。虽然以前有报道称犬的锰中毒可导致肝毒性，但兽医文献中尚未描述成功治疗锰中毒的方法。一只 5 岁已绝育的雌性设得兰牧羊犬和一只 5 岁的雌性设得兰牧羊犬在意外摄入关节补充剂后接受了评估。与毒理学家的咨询显示，担心锰中毒导致肝损伤。尽管进行了去污和最初使用 N-乙酰半胱氨酸和考来烯胺进行治疗，但这两只狗都随后发生了急性肝损伤。尽管使用了依地酸钙钠、对氨基水杨酸、别嘌醇、维生素 E、银杏叶和 S-腺苷甲硫氨酸/水飞蓟宾进行治疗，但这两只狗的肝值都恢复了正常。在一只狗中通过尿液锰分析和在另一只狗中通过粪便检查证实了锰暴露。以前的一份病例报告详细介绍了一只狗的致命锰中毒；本病例报告描述了成功治疗由锰中毒引起的严重急性肝损伤。上述药物的组合可能用于成功治疗犬的锰中毒。
