Alwiraikat-Flores Alamira Farah, Octavio-Aguilar Pablo
Laboratorio de Genética, Área Académica de Biología, Universidad Autónoma del Estado de Hidalgo, Hidalgo, México.
Biomedica. 2023 Mar 30;43(1):51-60. doi: 10.7705/biomedica.6704.
There are many factors involved in the incidence of Alzheimer’s disease that, in combination, impede or hinder normal neuronal functions. Little is currently known about calcium regulation before and during the disease. Internal instability of calcium levels is associated with increased vascular risk, a prevalent condition in a high number of individuals already compromised by Alzheimer’s disease. This review provides a reevaluation of the molecular mechanism of the sarcoendoplasmic reticulum calcium ATPase (SERC-A) in the disease and discusses salient aspects of voltage-gated calcium channel function; in these way new alternatives could be open for its treatment. These regulation mechanisms are clinically relevant since the irregular functions of SERC+A has been implicated in pathologies of brain function.
阿尔茨海默病的发病涉及多种因素，这些因素综合起来会阻碍或妨碍正常的神经元功能。目前对于该疾病发生之前及发病过程中的钙调节了解甚少。钙水平的内部不稳定与血管风险增加有关，而血管风险增加在大量已受阿尔茨海默病影响的个体中是一种普遍情况。本综述重新评估了肌浆网钙ATP酶（SERC-A）在该疾病中的分子机制，并讨论了电压门控钙通道功能的显著方面；通过这种方式，可以为其治疗开辟新的途径。这些调节机制具有临床相关性，因为SERC+A的功能异常与脑功能病理学有关。
