Department of Laboratory Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China.
School of Medicine & Institute for Life Sciences, South China University of Technology, Guangzhou 510006, China.
Int Immunopharmacol. 2023 Jun;119:110229. doi: 10.1016/j.intimp.2023.110229. Epub 2023 May 9.
Natural products have attracted extensive attention from researchers in medical fields due to their abundant biological activities. Parthenolide (PTL) is a sesquiterpene lactone originally purified from herb Feverfew (Tanacetum parthenium), recent studies have showed its potential activities of anti-cancer and anti-inflammatory. Acting as the most studied inflammasome, NLRP3 inflammasome played an important role in human diseases including type-2 diabetes (T2D), Alzheimer's disease (AD) and cryopyrin-associated periodic syndromes (CAPS). In this article, we show that PTL specially inhibits the activation of NLRP3 inflammation by block the upstream signal and prevent the assembly of NLRP3 inflammasome complex. Furthermore, we showed the treatment of PTL significantly attenuates the symptoms of lipopolysaccharide (LPS)-induced systemic inflammation and dextran sulfate sodium (DSS)-induced colitis in mice models. Thus, our results demonstrate that PTL alleviates inflammation by targeting NLRP3 inflammasome, which indicate that PTL acting as a promising natural product for the treatment of NLRP3 inflammasome-related diseases.
天然产物因其丰富的生物活性而引起了医学领域研究人员的广泛关注。小白菊内酯（PTL）是一种倍半萜内酯，最初从药草小白菊（Tanacetum parthenium）中纯化得到，最近的研究表明它具有潜在的抗癌和抗炎活性。作为研究最多的炎性体，NLRP3 炎性体在包括 2 型糖尿病（T2D）、阿尔茨海默病（AD）和 Cryopyrin 相关周期性综合征（CAPS）在内的人类疾病中发挥着重要作用。在本文中，我们表明 PTL 通过阻断上游信号专门抑制 NLRP3 炎症的激活，并阻止 NLRP3 炎性体复合物的组装。此外，我们还表明，PTL 治疗可显著减轻脂多糖（LPS）诱导的系统性炎症和葡聚糖硫酸钠（DSS）诱导的小鼠结肠炎模型中的症状。因此，我们的结果表明 PTL 通过靶向 NLRP3 炎性体缓解炎症，这表明 PTL 作为一种有前途的天然产物可用于治疗 NLRP3 炎性体相关疾病。
