味觉与疼痛：细菌性脑膜炎中的感官盛宴。
Taste vs. pain: A sensory feast in bacterial meningitis.
机构信息
Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105, USA.
Department of Infectious Diseases, St. Jude Children's Research Hospital, 262 Danny Thomas Pl, Memphis, TN 38105, USA.
出版信息
Cell Host Microbe. 2023 May 10;31(5):681-682. doi: 10.1016/j.chom.2023.04.006.
PMID:37167946
Abstract
During meningitis, sensory neurons detect bacterial toxins and metabolites. Early activation of pain receptors suppresses host defense in the meninges while, later, taste receptors amplify inflammation in the spinal cord. Is a neuroimmune axis a clue to new treatments?
摘要
在脑膜炎期间，感觉神经元会检测到细菌毒素和代谢物。疼痛受体的早期激活会抑制脑膜中的宿主防御，而随后，味觉受体则会加剧脊髓中的炎症。神经免疫轴是新疗法的线索吗？
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