Danielsen H, Pedersen E B, Nielsen A H, Herlevsen P, Kornerup H J, Posborg V
Acta Med Scand. 1986;219(4):399-405. doi: 10.1111/j.0954-6820.1986.tb03330.x.
Blood volume (BV), extracellular volume (ECV), blood pressure (BP), creatinine clearance (CCr), plasma levels of angiotensin II (AII), aldosterone (Aldo) and arginine vasopressin (AVP), and serum osmolality (Sosm) were determined in 18 patients with adult polycystic kidney disease, 8 normotensive (group I), 10 hypertensive (group II), and in 11 control subjects (group III). ECV but not BV was increased in group I compared with group III, whereas BV and ECV did not differ significantly between groups II and III. In group II, Aldo and AVP were increased and AII tended to be increased, while in group I the hormone levels did not differ significantly from those in group III. Sosm did not differ significantly between the groups. In the combined patient group, CCr correlated positively with BV and ECV and negatively with BP. In the patients, AII and AVP were positively correlated with BP but not with CCr. The results suggest that both the renin-angiotensin system and AVP might be involved in the BP elevation, whereas expansion of ECV can be found without an increase in BP.
对18例成年多囊肾病患者进行了血容量（BV）、细胞外液量（ECV）、血压（BP）、肌酐清除率（CCr）、血管紧张素II（AII）、醛固酮（Aldo）和精氨酸加压素（AVP）的血浆水平以及血清渗透压（Sosm）的测定，其中8例血压正常（I组），10例高血压患者（II组），并选取11名对照者作为III组。与III组相比，I组的ECV升高而BV未升高，而II组和III组之间的BV和ECV无显著差异。在II组中，Aldo和AVP升高，AII有升高趋势，而I组的激素水平与III组无显著差异。各组之间的Sosm无显著差异。在合并的患者组中，CCr与BV和ECV呈正相关，与BP呈负相关。在患者中，AII和AVP与BP呈正相关，但与CCr无关。结果表明，肾素-血管紧张素系统和AVP可能都与血压升高有关，而ECV的扩张在血压未升高的情况下也可出现。
