von Graffenried Thea, Schoepfer Alain M, Rossel Jean-Benoit, Greuter Thomas, Safroneeva Ekaterina, Godat Sébastien, Henchoz Sarah, Vavricka Stephan R, Sokollik Christiane, Spalinger Johannes, Braegger Christian P, Nydegger Andreas
From the Division of Pediatric Gastroenterology Hepatology and Nutrition, Centre Hospitalier Universitaire Vaudois [CHUV] and University of Lausanne, Lausanne, Switzerland.
Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois [CHUV] and University of Lausanne, Lausanne, Switzerland.
JPGN Rep. 2022 Mar 31;3(2):e193. doi: 10.1097/PG9.0000000000000193. eCollection 2022 May.
Given the paucity of data, we aimed to assess the impact of obesity on disease activity, complications, and quality of life (QoL) in pediatric inflammatory bowel disease (IBD) patients.
Prospective analysis of pediatric IBD patients. Patients were categorized into 4 groups according to the World Health Organization (WHO) child growth standards: obese, overweight, normal weight, and underweight.
Three hundred twenty-seven pediatric patients were included (146 with Crohn's disease [CD], 181 with ulcerative colitis of whom 13 [4%] were underweight, 272 [83.2%] had normal weight, 22 [6.7%] were overweight, and 20 [6.1%] were obese). Compared with normal weight patients, obese ulcerative colitis had a significantly higher clinical but not biological disease activity nor severity. Compared with normal weight patients, overweight/obese CD patients did not have higher clinical or biological disease activity nor severity. Perianal abscesses and surgery for this purpose were more frequently observed in overweight/obese CD patients compared with normal weight controls. Overweight/obese IBD patients were similarly hospitalized in the last 12 months compared with normal weight controls.
Prevalence of overweight/obesity was 12.8% in pediatric IBD patients. Obesity was not associated with a decrease in disease remission rates nor an increase in the risk of complicated disease progression in IBD pediatric patients, except for the occurrence of perianal abscesses and related surgery in CD patients.
鉴于数据匮乏，我们旨在评估肥胖对儿童炎症性肠病（IBD）患者疾病活动度、并发症及生活质量（QoL）的影响。
对儿童IBD患者进行前瞻性分析。根据世界卫生组织（WHO）儿童生长标准将患者分为4组：肥胖、超重、正常体重和体重不足。
纳入327例儿童患者（146例克罗恩病[CD]，181例溃疡性结肠炎，其中13例[4%]体重不足，272例[83.2%]体重正常，22例[6.7%]超重，20例[6.1%]肥胖）。与体重正常的患者相比，肥胖的溃疡性结肠炎患者临床疾病活动度显著更高，但生物学疾病活动度及严重程度并非如此。与体重正常的患者相比，超重/肥胖的CD患者临床或生物学疾病活动度及严重程度并未更高。与体重正常的对照组相比，超重/肥胖的CD患者肛周脓肿及为此进行的手术更为常见。与体重正常的对照组相比，超重/肥胖的IBD患者在过去12个月内住院情况相似。
儿童IBD患者中超重/肥胖的患病率为12.8%。肥胖与IBD儿童患者疾病缓解率降低或复杂疾病进展风险增加无关，除了CD患者中肛周脓肿及相关手术的发生。
