Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC.
The Center for Innovation in Pediatric Practice, The Research Institute, Nationwide Children's Hospital, Columbus, OH.
J Pediatr Gastroenterol Nutr. 2018 Nov;67(5):622-625. doi: 10.1097/MPG.0000000000002066.
The impact of obesity on pediatric Crohn disease (CD) remains poorly characterized. We aimed to evaluate disease-related outcomes in overweight and obese children with CD, compared to normal-weight children. We conducted a retrospective cohort study of children with newly diagnosed CD enrolled in the ImproveCareNow Network. Patients were stratified into normal weight, overweight, and obese groups using standardized weight percentiles. A total of 898 children were included, with 87 children (10%) being overweight and 43 children (5%) being obese; baseline characteristics were similar between groups. There was no significant difference in number of visits in remission during 1 year between normal weight, overweight, and obese children. At 1-year follow-up, nutritional status, growth status, or medication use also did not differ between groups. Hence, obesity does not appear to adversely affect CD outcomes in children with newly diagnosed CD in the first year after diagnosis.
肥胖对儿科克罗恩病（CD）的影响仍未得到充分描述。我们旨在评估超重和肥胖的 CD 患儿与体重正常的患儿相比，疾病相关结局的差异。我们对新诊断为 CD 的儿童进行了一项回顾性队列研究，这些儿童均来自于 ImproveCareNow 网络。患者使用标准化体重百分位数分为正常体重、超重和肥胖组。共纳入 898 例儿童，其中超重 87 例（10%），肥胖 43 例（5%）；各组间基线特征相似。在 1 年内缓解期间的就诊次数在正常体重、超重和肥胖儿童之间无显著差异。在 1 年随访时，营养状况、生长状况或药物使用在各组之间也没有差异。因此，在诊断后 1 年内，肥胖似乎不会对新诊断为 CD 的儿童的疾病结局产生不利影响。
