Rauhut F, Clar H E, Bamberg M, Benker G, Grote W
Acta Neurochir (Wien). 1986;80(3-4):73-8. doi: 10.1007/BF01812277.
The tumour recurrence rate of 210 patients with operated hypophysomas were investigated. Depending on the surgical approach, total or subtotal extirpation of the adenomas, the recurrence rates varied from 10,4 to 35%. 33 patients with pituitary tumour recurrences were followed up over a period of 20 years. Clinical symptoms CT-results at relapse are represented. Serum prolactin level (PRL) was determined before and after surgical and radiotherapy of PRL-producing adenomas. In these cases PRL can be accepted as a tumour marker. 13 patients with relapsed hypophysomas received local irradiation (5.7 MeV linear accelerator) after recurrence operation. An individual comparison in the same patient between surgical therapy alone and combined surgical and radiotherapy was possible. Based on the obtained experience with this combined treatment a therapy scheme using combined surgery and radiotherapy in pituitary tumours is suggested.
对210例接受手术治疗的垂体瘤患者的肿瘤复发率进行了调查。根据手术方式、腺瘤的全切除或次全切除情况，复发率在10.4%至35%之间。对33例垂体瘤复发患者进行了为期20年的随访。列出了复发时的临床症状和CT结果。测定了催乳素分泌型腺瘤手术和放疗前后的血清催乳素水平（PRL）。在这些病例中，PRL可被视为一种肿瘤标志物。13例垂体瘤复发患者在复发手术后接受了局部照射（5.7 MeV直线加速器）。可以对同一患者单独手术治疗与手术联合放疗进行个体比较。基于这种联合治疗获得的经验，提出了一种垂体瘤手术联合放疗的治疗方案。
