雷美替胺给药可增强小鼠的新物体识别和空间工作记忆。

Ramelteon administration enhances novel object recognition and spatial working memory in mice.

机构信息

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.

Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan; Institute for AI and Beyond, The University of Tokyo, Tokyo 113-0033, Japan; Center for Information and Neural Networks, National Institute of Information and Communications Technology, Suita City, Osaka, 565-0871, Japan.

出版信息

J Pharmacol Sci. 2023 Jun;152(2):128-135. doi: 10.1016/j.jphs.2023.04.002. Epub 2023 Apr 11.

DOI:10.1016/j.jphs.2023.04.002

PMID:37169477

Abstract

Ramelteon is used to ameliorate sleep disorders that negatively affect memory performance; however, it remains unknown whether ramelteon strengthens neutral memories, which do not involve reward or punishment. To address this, we monitored behavior of mice treated with vehicle/ramelteon while they performed a novel object recognition task and a spontaneous alternation task. Object memory performance in the novel object recognition task was improved only if ramelteon was injected before training, suggesting that ramelteon specifically enhances the acquisition of object recognition memory. Ramelteon also enhanced spatial working memory in the spontaneous alternation task. Altogether, acute ramelteon treatment enhances memory in quasi-natural contexts.

摘要

雷美替胺用于改善会对记忆表现产生负面影响的睡眠障碍；然而，雷美替胺是否能增强不涉及奖惩的中性记忆尚不清楚。为了解决这个问题，我们在小鼠进行新物体识别任务和自发交替任务时，监测给予载体/雷美替胺处理的小鼠的行为。只有在训练前注射雷美替胺，新物体识别任务中的物体记忆表现才会改善，这表明雷美替胺专门增强了物体识别记忆的获得。雷美替胺也增强了自发交替任务中的空间工作记忆。总的来说，急性雷美替胺治疗增强了准自然环境中的记忆。