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保留肾单位治疗局限性实性肾肿块

[Nephron sparing in the management of localized solid renal mass].

作者信息

Bodard Sylvain, Dariane Charles, Bibault Jean-Emmanuel, Boudhabhay Idris, Delavaud Christophe, Timsit Marc-Olivier, Verkarre Virginie, Méjean Arnaud, Hélénon Olivier, Guinebert Sylvain, Correas Jean-Michel

机构信息

AP-HP, hôpital Necker-Enfants-Malades, service d'imagerie adulte, 75015 Paris, France; Université de Paris-Cité, 75006 Paris, France; Sorbonne université, laboratoire d'imagerie biomédicale, CNRS, Inserm, Paris, France; Groupe de recherche interdisciplinaire francophone en onco-néphrologie (GRIFON), Paris, France.

Université de Paris-Cité, 75006 Paris, France; AP-HP, hôpital européen Georges-Pompidou, service d'urologie, 75015 Paris, France.

出版信息

Bull Cancer. 2024 Jul-Aug;111(7-8):720-732. doi: 10.1016/j.bulcan.2023.04.005. Epub 2023 May 9.

Abstract

Managing a malignant renal tumor requires, first of all, a reflection on the necessity of its treatment. It must consider the renal function, altered at the time of diagnosis in 50% of cases. The treatment method chosen depends on many factors, in particular, the predicted residual renal function, the risk of chronic kidney disease, the need for temporary or long-term dialysis, and overall long-term survival. Other factors include the size, position, and number of tumors and a hereditary tumor background. When a renal-sparing management alternative is available, total nephrectomy should no longer be performed in patients with small malignant renal masses (cT1a). This may consist of surgery (partial nephrectomy or lumpectomy), percutaneous thermo-ablation (by radiofrequency, microwave, or cryotherapy). In patients with limited life expectancy, imaging-based surveillance may be proposed to suggest treatment in case of local progression. Good coordination between urologist, radiologist, nephrologist, and sometimes radiotherapist should allow optimal management of patients with a malignant renal tumor with or without underlying renal failure.

摘要

处理恶性肾肿瘤首先需要考虑其治疗的必要性。必须考虑肾功能,在50%的病例中,诊断时肾功能已发生改变。所选择的治疗方法取决于许多因素,特别是预测的残余肾功能、慢性肾病的风险、临时或长期透析的需求以及总体长期生存率。其他因素包括肿瘤的大小、位置和数量以及遗传性肿瘤背景。当有保留肾的管理方案可供选择时,对于小的恶性肾肿块(cT1a)患者不应再进行全肾切除术。这可能包括手术(部分肾切除术或肿块切除术)、经皮热消融(通过射频、微波或冷冻疗法)。对于预期寿命有限的患者,可建议进行基于影像学的监测,以便在局部进展时提示治疗。泌尿科医生、放射科医生、肾病科医生,有时还有放疗科医生之间的良好协作,应能对有或无潜在肾衰竭的恶性肾肿瘤患者进行最佳管理。

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