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Revisiting the role of serine metabolism in hepatic lipogenesis.

作者信息

Yang Hong, Zhang Cheng, Turkez Hasan, Uhlen Mathias, Boren Jan, Mardinoglu Adil

机构信息

Science for Life Laboratory, KTH-Royal Institute of Technology, Stockholm, Sweden.

Department of Medical Biology, Faculty of Medicine, Atatürk University, Erzurum, Turkey.

出版信息

Nat Metab. 2023 May;5(5):760-761. doi: 10.1038/s42255-023-00792-0. Epub 2023 May 11.

DOI:10.1038/s42255-023-00792-0
PMID:37169876
Abstract
摘要

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本文引用的文献

1
Insulin-regulated serine and lipid metabolism drive peripheral neuropathy.胰岛素调节的丝氨酸和脂质代谢驱动周围神经病。
Nature. 2023 Feb;614(7946):118-124. doi: 10.1038/s41586-022-05637-6. Epub 2023 Jan 25.
2
Renal UTX-PHGDH-serine axis regulates metabolic disorders in the kidney and liver.肾脏 UTX-PHGDH-丝氨酸轴调节肝肾代谢紊乱。
Nat Commun. 2022 Jul 4;13(1):3835. doi: 10.1038/s41467-022-31476-0.
3
Serine catabolism generates liver NADPH and supports hepatic lipogenesis.丝氨酸分解代谢产生肝脏 NADPH 并支持肝内脂肪生成。
一种绘制线粒体特化与可塑性图谱的定量方法。
bioRxiv. 2025 Feb 8:2025.02.03.635951. doi: 10.1101/2025.02.03.635951.
Nat Metab. 2021 Dec;3(12):1608-1620. doi: 10.1038/s42255-021-00487-4. Epub 2021 Nov 29.
4
Combined metabolic activators therapy ameliorates liver fat in nonalcoholic fatty liver disease patients.联合代谢激活剂治疗可改善非酒精性脂肪性肝病患者的肝脂肪。
Mol Syst Biol. 2021 Oct;17(10):e10459. doi: 10.15252/msb.202110459.
5
The emerging role of one-carbon metabolism in T cells.一碳代谢在 T 细胞中的新兴作用。
Curr Opin Biotechnol. 2021 Apr;68:193-201. doi: 10.1016/j.copbio.2020.12.001. Epub 2021 Jan 7.
6
The acute effect of metabolic cofactor supplementation: a potential therapeutic strategy against non-alcoholic fatty liver disease.代谢辅因子补充的急性作用:一种针对非酒精性脂肪性肝病的潜在治疗策略。
Mol Syst Biol. 2020 Apr;16(4):e9495. doi: 10.15252/msb.209495.
7
Pentose phosphate pathway activity parallels lipogenesis but not antioxidant processes in rat liver.戊糖磷酸途径活性与大鼠肝脏的脂肪生成平行,但与抗氧化过程无关。
Am J Physiol Endocrinol Metab. 2018 Jun 1;314(6):E543-E551. doi: 10.1152/ajpendo.00342.2017. Epub 2018 Jan 9.
8
Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance.非酒精性脂肪性肝病中氨基酸浓度的改变:肥胖和胰岛素抵抗的影响。
Hepatology. 2018 Jan;67(1):145-158. doi: 10.1002/hep.29465. Epub 2017 Nov 17.
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Personal model-assisted identification of NAD and glutathione metabolism as intervention target in NAFLD.基于个体模型辅助识别NAD和谷胱甘肽代谢作为非酒精性脂肪性肝病的干预靶点。
Mol Syst Biol. 2017 Mar 2;13(3):916. doi: 10.15252/msb.20167422.
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Clin Gastroenterol Hepatol. 2016 Oct;14(10):1463-1472.e6. doi: 10.1016/j.cgh.2016.05.046. Epub 2016 Jun 16.