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[细胞增殖与癌症的动力学:引言(作者译)]

[Kinetics of cell proliferation and cancer: introduction (author's transl)].

作者信息

Tubiana M

出版信息

Bull Cancer. 1978;65(4):407-15.

PMID:371706
Abstract

Research in the kinetics of cell proliferation directly interests oncologists for fundamental and pragmatic reasons. Since cancer is a perturbation of the control of cell proliferation and differentiation, such research may help to understand, the regulation mechanisms, in particular the role of microenvironment, of long range humoral factors, and of membrane site receptors. Furthermore the kinetics of cell proliferation in a normal tissue, or a tumour, influences its response to radiation or drugs. From this evolves the practical interest in research on hemopoietic tissues and on human and experimental tumors. Finally, the growth kinetics of human tumors explain their natural history and opens prospects for the treatment of intraclinical neoplastic disease and metastasis.

摘要

出于基础和实际的原因,细胞增殖动力学的研究直接引起了肿瘤学家的兴趣。由于癌症是细胞增殖和分化控制的一种紊乱,此类研究可能有助于了解调节机制,特别是微环境、远距离体液因子和膜位点受体的作用。此外,正常组织或肿瘤中细胞增殖的动力学影响其对辐射或药物的反应。由此产生了对造血组织以及人类和实验性肿瘤研究的实际兴趣。最后,人类肿瘤的生长动力学解释了它们的自然病程,并为临床肿瘤疾病和转移的治疗开辟了前景。

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