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18F-FDG 和 68Ga-DOTATATE PET/CT 在神经内分泌肿瘤中的应用比较：一项回顾性研究。

Comparison of the application of 18F-FDG and 68Ga-DOTATATE PET/CT in neuroendocrine tumors: A retrospective study.

机构信息

Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Department of Obstetrics, Zunyi Hospital of Traditional Chinese Medicine, Zunyi, China.

出版信息

Medicine (Baltimore). 2023 May 12;102(19):e33726. doi: 10.1097/MD.0000000000033726.

DOI:10.1097/MD.0000000000033726
PMID:37171344
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10174405/
Abstract

The present study aimed to compare the efficacy of 68Ga-DOTATATE PET/CT and 18F-FDG PET/CT imaging in the diagnosis, staging, and prognosis evaluation of neuroendocrine tumors (NET). A total of 55 patients (43 were initially evaluated, 12 were evaluated after treatment) who underwent fluorine-18 labeled fluorodeoxyglucose (18F-FDG) and 68Ga DOTATE PET/CT examinations were reviewed retrospectively, and the pathological data were collected. In the initial evaluation, 27/43 were pathologically confirmed as NET patients, as detected by gallium-68 labeld 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraaceticacid-D-Phel-Tyr3-Thr8-OC; among them, 23 were correctly detected by 18F-FDG. In lesion-based comparison, 119/168 focal lesions were depicted on 18F-FDG PET/CT and 68Ga-DOTATATE PET/CT, respectively (P = .0363). Strikingly, gallium-68 labeld 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraaceticacid-D-Phel-Tyr3-Thr8-OC had higher maximum standard uptake value than 18F-FDG but was negatively related to the NET grade for the former, while the latter was positively related to the NET. The value of 68Ga-DOTATATE PET/CT in the diagnosis and staging of NET is higher than that of 18F-FDG PET/CT in NETs, while the value of 18F-FDG PET/CT cannot be ignored in the NET. The combined application of the 2 tracers has major clinical significance in the management of patients with NET.

摘要

本研究旨在比较 68Ga-DOTATATE PET/CT 和 18F-FDG PET/CT 成像在神经内分泌肿瘤（NET）的诊断、分期和预后评估中的疗效。回顾性分析了 55 例（43 例初诊，12 例治疗后）接受氟-18 标记氟脱氧葡萄糖（18F-FDG）和 68Ga DOTATATE PET/CT 检查的患者，收集了病理数据。在初诊中，43 例患者中 27 例经病理学证实为 NET 患者，通过镓-68 标记 1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸-D-Phel-Tyr3-Thr8-OC 检测；其中，18F-FDG 正确检测 23 例。基于病变的比较，18F-FDG PET/CT 和 68Ga-DOTATATE PET/CT 分别显示 168 个局灶性病变中的 119 个（P =.0363）。值得注意的是，68Ga 标记的 1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸-D-Phel-Tyr3-Thr8-OC 的最大标准摄取值高于 18F-FDG，但与前者的 NET 分级呈负相关，而后者与 NET 呈正相关。68Ga-DOTATATE PET/CT 对 NET 的诊断和分期价值高于 18F-FDG PET/CT，而 18F-FDG PET/CT 在 NET 中也不容忽视。两种示踪剂的联合应用对 NET 患者的管理具有重要的临床意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abfa/10174405/508cdd0c47f8/medi-102-e33726-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abfa/10174405/a35e11337a27/medi-102-e33726-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abfa/10174405/fd075cf6236d/medi-102-e33726-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abfa/10174405/508cdd0c47f8/medi-102-e33726-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abfa/10174405/a35e11337a27/medi-102-e33726-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abfa/10174405/fd075cf6236d/medi-102-e33726-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abfa/10174405/508cdd0c47f8/medi-102-e33726-g003.jpg

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引用本文的文献

[1]
[Ga-DOTATATE and F-FDG PET/CT dual-modality imaging enhances precision of staging and treatment decision for gastroenteropancreatic neuroendocrine neoplasms].

Nan Fang Yi Ke Da Xue Xue Bao. 2025-6-20

[2]
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Front Med (Lausanne). 2025-5-9

[3]
Case Report: Pulmonary sclerosing pneumocytoma mimicking as a neuroendocrine tumor on F-FDG and Ga-DOTATATE PET/CT: a case presentation.

Front Oncol. 2025-2-21

[4]
CT, MRI, and PET/CT imaging features of thoracic spine epithelioid hemangioma: a retrospective observational study.

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[5]
Diagnosis of pancreatic focal nesidioblastosis assisted by dual‑nuclide tracer positron emission tomography/computed tomography: A case report.

Exp Ther Med. 2023-11-28

[6]
Surgical treatment of primary hepatic neuroendocrine tumor diagnosed by AlF-NOTA-Octreotide PET/CT: a case report.

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本文引用的文献

[1]
F-AlF-NOTA-Octreotide Outperforms Ga-DOTATATE/NOC PET in Neuroendocrine Tumor Patients: Results from a Prospective, Multicenter Study.

J Nucl Med. 2023-4

[2]
Performance and long-term consistency of five Galliform 68Ge/68Ga generators used for clinical Ga-68 preparations over a 4 year period.

Nucl Med Commun. 2022-5-1

[3]
Prognostic Value of Whole-Body PET Volumetric Parameters Extracted from Ga-DOTATOC PET/CT in Well-Differentiated Neuroendocrine Tumors.

J Nucl Med. 2022-7

[4]
Comparison of 68Ga-DOTANOC and 18F-FDG PET-CT Scans in the Evaluation of Primary Tumors and Lymph Node Metastasis in Patients With Rectal Neuroendocrine Tumors.

Front Endocrinol (Lausanne). 2021

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Somatostatin Receptor Imaging and Theranostics: Current Practice and Future Prospects.

J Nucl Med. 2021-10

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Head-to-Head Comparison of Ga-DOTA-JR11 and Ga-DOTATATE PET/CT in Patients with Metastatic, Well-Differentiated Neuroendocrine Tumors: A Prospective Study.

J Nucl Med. 2019-11-1

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Theranostics. 2017-3-1

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J Nucl Med. 2016-12

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Best Pract Res Clin Endocrinol Metab. 2016-1

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