Yu Ronghua, Zhao Wei, Yu Yonglin, Hu Xianwen
Affiliated Hospital of Zunyi Medical University, Department of Nuclear Medicine, Zunyi, China.
Department of Pathology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Front Oncol. 2025 Feb 21;15:1511595. doi: 10.3389/fonc.2025.1511595. eCollection 2025.
Pulmonary sclerosing pneumocytoma (PSP) is a relatively rare benign lung tumor, and it is difficult to obtain an accurate diagnosis before surgery. Herein, we present a case of 34-year-old woman who came to our hospital for medical help due to cough and sputum for one month. She underwent a chest computed tomography (CT) scan which revealed a circular soft tissue density shadow in the upper lobe of the left lung. A needle biopsy was subsequently performed which revealed a probable lung carcinoid. To further evaluate the nature of the mass and determine a treatment plan, the patient subsequently underwent dual nuclide tracer including fluorine-18 labeled fluorodeoxyglucose (F-FDG) and gallium-68 labeled 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7,10-tetraaceticacid -D-Phel-Tyr3-Thr8-OC (Ga-DOTATATE) PET/CT imaging. The results showed that the lession presented increased both F-FDG and Ga-DOTATATE uptake, suggesting a neuroendocrine tumor. However, postoperative pathology confirmed that the lesion was PSP. Our case study suggests that PSP may presents varying degrees of increased F-FDG and Ga-DOTATATE uptake on positron emission tomography (PET)/CT imaging, which should be considered as one of the differential diagnoses for lung carcinoids.
肺硬化性肺细胞瘤(PSP)是一种相对罕见的良性肺肿瘤,术前很难获得准确诊断。在此,我们报告一例34岁女性患者,因咳嗽、咳痰1个月前来我院就诊。她接受了胸部计算机断层扫描(CT),结果显示左肺上叶有一个圆形软组织密度影。随后进行了针吸活检,结果显示可能为肺类癌。为进一步评估肿块性质并确定治疗方案,患者随后接受了包括氟-18标记的氟脱氧葡萄糖(F-FDG)和镓-68标记的1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸-D-苯丙氨酸-Tyr3-苏氨酸8-奥曲肽(Ga-DOTATATE)的双核素示踪剂PET/CT成像。结果显示,该病灶F-FDG和Ga-DOTATATE摄取均增加,提示为神经内分泌肿瘤。然而,术后病理证实该病灶为PSP。我们的病例研究表明,PSP在正电子发射断层扫描(PET)/CT成像上可能表现出不同程度的F-FDG和Ga-DOTATATE摄取增加,这应被视为肺类癌的鉴别诊断之一。