Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Hum Reprod. 2023 Aug 1;38(8):1429-1444. doi: 10.1093/humrep/dead087.
The aetiology behind many female reproductive disorders is poorly studied and incompletely understood despite the prevalence of such conditions and substantial burden they impose on women's lives. In light of evidence demonstrating a higher incidence of trauma exposure in women with many such disorders, we present a set of interlinked working hypotheses proposing relationships between traumatic events and reproductive and mental health that can define a research agenda to better understand reproductive outcomes from a trauma-informed perspective across the lifecourse. Additionally, we note the potential for racism to act as a traumatic experience, highlight the importance of considering the interaction between mental and reproductive health concerns, and propose several neuroendocrinological mechanisms by which traumatic experiences might increase the risk of adverse health outcomes in these domains. Finally, we emphasize the need for future primary research investigating the proposed pathways between traumatic experiences and adverse female reproductive outcomes.
尽管许多女性生殖障碍的病因研究不足，且人们对其了解程度有限，但这些病症的普遍性及其对女性生活造成的巨大负担不容忽视。鉴于有证据表明，许多此类疾病的女性创伤暴露发生率更高，我们提出了一系列相互关联的工作假设，这些假设提出了创伤事件与生殖和心理健康之间的关系，可确定一个研究议程，以便从创伤知情的角度在整个生命周期更好地理解生殖结果。此外，我们注意到种族主义可能成为一种创伤性经历，并强调必须考虑精神和生殖健康问题之间的相互作用，提出了一些神经内分泌机制，说明创伤经历如何增加这些领域不良健康结果的风险。最后，我们强调需要开展未来的基础研究，以调查创伤经历与不良女性生殖结果之间的拟议途径。
