State Key Laboratory Coal Resources and Safe Mining, China University of Mining and Technology-Beijing, Ding11 Xueyuan Road, Beijing 100083, China.
School of Chemical and Environmental Engineering, China University of Mining and Technology-Beijing, Ding11 Xueyuan Road, Beijing 100083, China.
Molecules. 2023 Apr 30;28(9):3827. doi: 10.3390/molecules28093827.
Asthma is a common chronic inflammatory disease of the airways with no known cure. Lipid mediators (LMs) are a kind of inflammatory signaling molecules which are believed to be involved in the development of asthma. Boriss. is a traditional Uyghur medicine, which is widely used in the treatment of asthma and other respiratory diseases. Extraction of Boriss. was reported to neutralize asthma symptoms. The purpose of the study was to investigate both the anti-inflammatory and immunoregulation properties of the Boriss. extract (SXCF) and its main active constituent, rosmarinic acid (RosA), in vivo. The effect of RosA, a major constituent of SXCF, was evaluated on an asthmatic model, with both anti-inflammatory and immunoregulation properties.
Anti-inflammatory effect of SXCF and RosA was assessed using OVA-induced asthma model mice by UPLC-MS/MS method.
Overall, RosA played a critical role in anti-asthma treatment. In total, 90% of LMs species that were significantly regulated by SXCF were covered. On the most important LMs associated with asthma, RosA equivalent induced similar effects as SXCF did. It is believed that some constituents in SXCF could neutralize RosA excessive impacts on LMs.
哮喘是一种常见的气道慢性炎症性疾病，目前尚无治愈方法。脂类介质（LMs）是一种炎症信号分子，被认为参与了哮喘的发生发展。Boriss. 是一种传统的维吾尔药物，广泛用于治疗哮喘和其他呼吸系统疾病。Boriss. 的提取被报道可以中和哮喘症状。本研究旨在研究 Boriss. 提取物（SXCF）及其主要活性成分迷迭香酸（RosA）的体内抗炎和免疫调节特性。评估 RosA（SXCF 的主要成分之一）对具有抗炎和免疫调节特性的哮喘模型的影响。
采用 UPLC-MS/MS 方法评估 SXCF 和 RosA 对卵清蛋白诱导的哮喘模型小鼠的抗炎作用。
总的来说，RosA 在抗哮喘治疗中起着关键作用。共有 90%受 SXCF 显著调节的 LMs 种类被涵盖。在与哮喘最相关的重要 LMs 中，RosA 当量产生的效果与 SXCF 相似。据信，SXCF 中的一些成分可以中和 RosA 对 LMs 的过度影响。
