Pain Research Center, Department of Anesthesiology, Medical Center, University of Cincinnati, Cincinnati, OH 45219, USA.
Neuroscience Graduate Program, College of Medicine, University of Cincinnati, Cincinnati, OH 45267, USA.
Int J Mol Sci. 2023 Apr 26;24(9):7897. doi: 10.3390/ijms24097897.
Migraine is a neurovascular disorder that affects approximately 12% of the global population. While its exact causes are still being studied, researchers believe that nociceptive neurons in the trigeminal ganglia play a key role in the pain signals of migraine. These nociceptive neurons innervate the intracranial meninges and convey pain signals from the meninges to the thalamus. Targeting nociceptive neurons is considered promising due to their accessibility and distinct molecular profile, which includes the expression of several transient receptor potential (TRP) channels. These channels have been linked to various pain conditions, including migraine. This review discusses the role and mechanisms of nociceptive neurons in migraine, the challenges of current anti-migraine drugs, and the evidence for well-studied and emerging TRP channels, particularly TRPC4, as novel targets for migraine prevention and treatment.
偏头痛是一种影响全球约 12%人口的神经血管疾病。虽然其确切病因仍在研究中，但研究人员认为三叉神经节中的伤害感受神经元在偏头痛的疼痛信号中发挥着关键作用。这些伤害感受神经元支配颅内脑膜，并将脑膜的疼痛信号传递到丘脑。由于伤害感受神经元易于接近且具有独特的分子特征，包括表达几种瞬时受体电位 (TRP) 通道，因此靶向伤害感受神经元被认为是有前途的。这些通道与包括偏头痛在内的各种疼痛状况有关。本文讨论了伤害感受神经元在偏头痛中的作用和机制、现有抗偏头痛药物的挑战，以及研究充分和新兴的 TRP 通道（特别是 TRPC4）作为偏头痛预防和治疗的新靶点的证据。
