Barbieri Moira, Zamagni Giulia, Fantasia Ilaria, Monasta Lorenzo, Lo Bello Leila, Quadrifoglio Mariachiara, Ricci Giuseppe, Maso Gianpaolo, Piccoli Monica, Di Martino Daniela Denis, Ferrazzi Enrico Mario, Stampalija Tamara
Department of Mother and Neonate, Institute for Maternal and Child Health IRCCS "Burlo Garofolo", 34100 Trieste, Italy.
Clinical Epidemiology and Public Health Research Unit, Institute for Maternal and Child Health IRCCS "Burlo Garofolo", 34100 Trieste, Italy.
J Clin Med. 2023 Apr 26;12(9):3132. doi: 10.3390/jcm12093132.
The objectives of the study were (1) to perform a systematic review of the available umbilical vein blood flow volume (UV-Q) reference ranges in uncomplicated pregnancies; and (2) to compare the findings of the systematic review with UV-Q values obtained from a local cohort. Available literature in the English language on this topic was identified following the PRISMA guidelines. Selected original articles were further grouped based on the UV sampling sites and the formulae used to compute UV-Q. The 50th percentiles, the means, or the best-fitting curves were derived from the formulae or the reported tables presented by authors. A prospective observational study of uncomplicated singleton pregnancies from 20 to 40 weeks of gestation was conducted to compare UV-Q with the results of this systematic review. Fifteen sets of data (fourteen sets belonging to manuscripts identified by the research strategy and one obtained from our cohort) were compared. Overall, there was a substantial heterogeneity among the reported UV-Q central values, although when using the same sampling methodology and formulae, the values overlap. Our data suggest that when adhering to the same methodology, the UV-Q assessment is accurate and reproducible, thus encouraging further investigation on the possible clinical applications of this measurement in clinical practice.
（1）对单纯性妊娠中可用的脐静脉血流量（UV-Q）参考范围进行系统评价；（2）将系统评价的结果与从本地队列中获得的UV-Q值进行比较。按照PRISMA指南检索了关于该主题的英文现有文献。所选的原始文章根据脐静脉采样部位和用于计算UV-Q的公式进一步分组。第50百分位数、均值或最佳拟合曲线是根据作者给出的公式或报告的表格得出的。进行了一项对妊娠20至40周的单纯性单胎妊娠的前瞻性观察研究，以将UV-Q与该系统评价的结果进行比较。比较了15组数据（14组属于通过研究策略确定的手稿数据，1组来自我们的队列）。总体而言，报告的UV-Q中心值之间存在很大异质性，不过当使用相同的采样方法和公式时，这些值会有重叠。我们的数据表明，当采用相同的方法时，UV-Q评估是准确且可重复的，从而鼓励进一步研究该测量方法在临床实践中可能的临床应用。
