Parving A, Ostri B, Bretlau P, Hansen J M, Parving H H
Ann Otol Rhinol Laryngol. 1986 May-Jun;95(3 Pt 1):278-83. doi: 10.1177/000348948609500313.
Fifteen patients with confirmed myxedema at a median age of 48 years (range 32 to 60 years) were referred for audiological evaluation before and after treatment with levothyroxine. The median interval between the pretreatment and posttreatment investigations was 18 months (range 9 to 27 months). In addition, 13 patients at a median age of 78 years (range 64 to 95 years) were audiologically reexamined after long-standing levothyroxine treatment. The observation period upon treatment with levothyroxine was 40 months (range 32 to 46 months). No improvement in hearing sensitivity could be demonstrated either in the younger patients or in the elderly. When compared to an age- and sex-matched unscreened population, the myxedematous patients did not demonstrate any different degree of hearing loss. Histological investigation of the temporal bones from an 83-year-old woman with myxedema, however, showed no morphological changes or deposition of glycosaminoglycans, changes which are compatible with true age-related hearing loss. It is concluded that no association exists between myxedema and hearing impairment and that no morphological or structural changes due to myxedema can be demonstrated in the temporal bones.
15名确诊为黏液性水肿的患者，年龄中位数为48岁（范围32至60岁），在接受左甲状腺素治疗前后接受了听力学评估。治疗前和治疗后检查之间的间隔中位数为18个月（范围9至27个月）。此外，13名年龄中位数为78岁（范围64至95岁）的患者在长期接受左甲状腺素治疗后接受了听力学复查。左甲状腺素治疗的观察期为40个月（范围32至46个月）。年轻患者和老年患者的听力敏感度均未显示出改善。与年龄和性别匹配的未筛查人群相比，黏液性水肿患者未表现出任何不同程度的听力损失。然而，对一名83岁黏液性水肿女性的颞骨进行组织学检查，未发现形态学变化或糖胺聚糖沉积，这些变化与真正的年龄相关性听力损失相符。结论是黏液性水肿与听力障碍之间不存在关联，且在颞骨中未发现由黏液性水肿引起的形态学或结构变化。
