通过造血干细胞移植治愈 HIV-1 感染的证据整理。
Curating evidence for a cure of HIV-1 infection by hematopoietic stem cell transplantation.
机构信息
Ragon Institute of MGH, MIT and Harvard, Cambridge, MA 02139, USA; Infectious Disease Division, Brigham and Women's Hospital, Boston, MA 02115, USA.
出版信息
Med. 2023 May 12;4(5):285-287. doi: 10.1016/j.medj.2023.04.006.
Abstract
A cure of HIV-1 infection has previously been described in two individuals undergoing allogeneic hematopoietic stem cell transplants from homozygous carriers of the CCR5Δ32 gene variant, which confers HIV-1 resistance. Two recent reports corroborate these earlier studies, underscoring that in HIV-1-infected persons with hematologic malignancies, these procedures may provide a realistic perspective for a cure of HIV-1 infection.
摘要
此前有两例接受来自 CCR5Δ32 基因变异纯合子携带者的同种异体造血干细胞移植的 HIV-1 感染者被治愈，该变异可赋予 HIV-1 抗性。最近的两项研究报告证实了这些早期研究，强调在患有血液系统恶性肿瘤的 HIV-1 感染者中，这些治疗方法可能为治愈 HIV-1 感染提供现实的前景。
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