通过CCR5 Δ32/Δ32干细胞移植实现对HIV的长期控制。
Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation.
作者信息
Hütter Gero, Nowak Daniel, Mossner Maximilian, Ganepola Susanne, Müssig Arne, Allers Kristina, Schneider Thomas, Hofmann Jörg, Kücherer Claudia, Blau Olga, Blau Igor W, Hofmann Wolf K, Thiel Eckhard
机构信息
Department of Hematology, Oncology, and Transfusion Medicine, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Germany.
出版信息
N Engl J Med. 2009 Feb 12;360(7):692-8. doi: 10.1056/NEJMoa0802905.
Infection with the human immunodeficiency virus type 1 (HIV-1) requires the presence of a CD4 receptor and a chemokine receptor, principally chemokine receptor 5 (CCR5). Homozygosity for a 32-bp deletion in the CCR5 allele provides resistance against HIV-1 acquisition. We transplanted stem cells from a donor who was homozygous for CCR5 delta32 in a patient with acute myeloid leukemia and HIV-1 infection. The patient remained without viral rebound 20 months after transplantation and discontinuation of antiretroviral therapy. This outcome demonstrates the critical role CCR5 plays in maintaining HIV-1 infection.
感染1型人类免疫缺陷病毒（HIV-1）需要存在CD4受体和趋化因子受体，主要是趋化因子受体5（CCR5）。CCR5等位基因中32个碱基对缺失的纯合性可提供对HIV-1感染的抗性。我们将来自一名CCR5 delta32纯合供体的干细胞移植到一名患有急性髓性白血病和HIV-1感染的患者体内。该患者在移植后并停用抗逆转录病毒治疗20个月后仍未出现病毒反弹。这一结果证明了CCR5在维持HIV-1感染中所起的关键作用。
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