Oster O, Drexler M, Schenk J, Meinertz T, Kasper W, Schuster C J, Prellwitz W
Ann Clin Res. 1986;18(1):36-42.
Serum selenium concentration was determined in 49 patients with acute myocardial infarction within 4 hours after the beginning of the symptoms. The mean serum selenium concentration of the patients was significantly lower than that of healthy controls (55 +/- 15 micrograms/l vs. 78 +/- 11 micrograms/l). Among the 49 patients with acute myocardial infarction 20 (41%) had serum selenium concentration below the 95% percentile of the healthy control group. It is concluded that the low serum selenium concentration was present in these patients before the acute event and was not a consequence of the myocardial infarction. No relationship was found in this study between the serum selenium concentration and the severity of myocardial infarction if the number of coronary vessels occluded is taken as the criterion of severity. Serum selenium concentration was similar in patients with 1 or more coronary vessels occluded. Patients with anterior or posterior myocardial infarction had similar serum selenium concentrations. A positive correlation was observed between serum selenium concentration and total serum creatine kinase (CK) activity and serum myoglobin (MB). The serum selenium concentration correlated negatively with the ratio CK-MB/total CK activity, which can be interpreted as minor injury of mitochondria during infarction in patients with normal serum selenium concentration.
在症状出现后4小时内，对49例急性心肌梗死患者测定了血清硒浓度。患者的平均血清硒浓度显著低于健康对照组（55±15微克/升对78±11微克/升）。在49例急性心肌梗死患者中，20例（41%）的血清硒浓度低于健康对照组的第95百分位数。得出的结论是，这些患者在急性事件发生前血清硒浓度就较低，并非心肌梗死的结果。如果以闭塞冠状动脉血管的数量作为严重程度的标准，本研究未发现血清硒浓度与心肌梗死严重程度之间存在关联。1支或更多冠状动脉血管闭塞的患者血清硒浓度相似。前壁或后壁心肌梗死患者的血清硒浓度相似。观察到血清硒浓度与血清总肌酸激酶（CK）活性及血清肌红蛋白（MB）呈正相关。血清硒浓度与CK-MB/总CK活性比值呈负相关，这可解释为血清硒浓度正常的患者在梗死期间线粒体损伤较轻。
