Biomedical Orthopaedic Research Group, Centre for Orthopaedic & Trauma Research, The University of Adelaide, Adelaide, South Australia, Australia; Centre for Orthopaedic & Trauma Research, The University of Adelaide, Adelaide, South Australia, Australia.
Centre for Orthopaedic & Trauma Research, The University of Adelaide, Adelaide, South Australia, Australia.
Osteoarthritis Cartilage. 2023 Sep;31(9):1224-1233. doi: 10.1016/j.joca.2023.05.005. Epub 2023 May 11.
It is unclear if different factors influence osteoarthritis (OA) progression and degenerative changes characterising OA disease in hip and knee. We investigated the difference between hip OA and knee OA at the subchondral bone (SCB) tissue and cellular level, relative to the degree of cartilage degeneration.
Bone samples were collected from 11 patients (aged 70.4 ± 10.7years) undergoing knee arthroplasty and 8 patients (aged 62.3 ± 13.4years) undergoing hip arthroplasty surgery. Trabecular bone microstructure, osteocyte-lacunar network, and bone matrix vascularity were evaluated using synchrotron micro-CT imaging. Additionally, osteocyte density, viability, and connectivity were determined histologically.
The associations between severe cartilage degeneration and increase of bone volume fraction (%) [- 8.7, 95% CI (-14.1, -3.4)], trabecular number (#/mm) [- 1.5, 95% CI (-0.8, -2.3)], osteocyte lacunar density (#/mm) [4714.9; 95% CI (2079.1, 7350.6)] and decrease of trabecular separation (mm) [- 0.07, 95% CI (0.02, 0.1)] were found in both knee and hip OA. When compared to knee OA, hip OA was characterised by larger (µm) but less spheric osteocyte lacunae [47.3; 95% CI (11.2, 83.4), - 0.04; 95% CI (-0.06, -0.02), respectively], lower vascular canal density (#/mm) [- 22.8; 95% CI (-35.4, -10.3)], lower osteocyte cell density (#/mm) [- 84.2; 95% CI (-102.5, -67.4)], and less senescent (#/mm) but more apoptotic osteocytes (%) [- 2.4; 95% CI (-3.6, -1.2), 24.9; 95% CI (17.7, 32.1)], respectively.
SCB from hip OA and knee OA exhibits different characteristics at the tissue and cellular levels, suggesting different mechanisms of OA progression in different joints.
目前尚不清楚是否有不同的因素会影响髋关节和膝关节骨关节炎（OA）的进展以及OA 疾病的退行性变化特征。我们研究了髋关节 OA 和膝关节 OA 在软骨退变程度相同时，在软骨下骨（SCB）组织和细胞水平上的差异。
从 11 名（年龄 70.4±10.7 岁）接受膝关节置换术和 8 名（年龄 62.3±13.4 岁）接受髋关节置换术的患者中采集骨样本。使用同步加速器微 CT 成像评估小梁骨微观结构、骨细胞陷窝网络和骨基质血管化。此外，还通过组织学方法确定了骨细胞密度、活力和连通性。
在膝关节和髋关节 OA 中均发现严重软骨退变与骨体积分数（%）增加[-8.7，95%置信区间（-14.1，-3.4）]、骨小梁数量（#/mm）[-1.5，95%置信区间（-0.8，-2.3）]、骨细胞陷窝密度（#/mm）[4714.9；95%置信区间（2079.1，7350.6）]和骨小梁分离（mm）减少[-0.07，95%置信区间（0.02，0.1）]之间存在关联。与膝关节 OA 相比，髋关节 OA 的特点是骨细胞陷窝更大（µm）但更呈球形[47.3；95%置信区间（11.2，83.4），-0.04；95%置信区间（-0.06，-0.02）]，血管管腔密度（#/mm）更低[-22.8；95%置信区间（-35.4，-10.3）]，骨细胞密度（#/mm）更低[-84.2；95%置信区间（-102.5，-67.4）]，衰老的骨细胞（#/mm）更少[-2.4；95%置信区间（-3.6，-1.2）]，凋亡的骨细胞（%）更多[24.9；95%置信区间（17.7，32.1）]。
髋关节 OA 和膝关节 OA 的 SCB 在组织和细胞水平上表现出不同的特征，这表明不同关节 OA 进展的机制不同。
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